Loading…

A case‐control study of the risk factors for developing aspergillosis following cardiac transplant

Background Invasive aspergillosis (IA) is a significant cause of morbidity and mortality following cardiac transplantation; however, data regarding the predictors of IA in this patient population are limited. Methods We conducted a case‐control study to identify the risk factors for IA in patients w...

Full description

Saved in:
Bibliographic Details
Published in:Clinical transplantation 2018-09, Vol.32 (9), p.e13367-n/a
Main Authors: Cook, Jennifer C., Cook, Abigail, Tran, Richard H., Chang, Patricia P., Rodgers, Jo E.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Invasive aspergillosis (IA) is a significant cause of morbidity and mortality following cardiac transplantation; however, data regarding the predictors of IA in this patient population are limited. Methods We conducted a case‐control study to identify the risk factors for IA in patients who underwent cardiac transplantation at a single center from 1986 to 2008 (Cohort 1) and 2009 to 2015 (Cohort 2). Cases of IA were matched to two controls from the same year of transplantation, and data were collected from the date of cardiac transplantation to the date of documented Aspergillus infection for each case, or for an equivalent number of days for each control. Univariate and multivariate logistic regressions were used to identify independent predictors of IA in Cohort 1. After 2009, targeted antifungal prophylaxis with oral voriconazole was initiated in patients with risk factors for IA. The incidence of IA was compared pre‐ and postintervention. Results IA was identified in 23 of 189 (8.0%) patients within Cohort 1. Significant risk factors for IA on multivariate analysis included an increased number of pretransplant hospitalizations (OR 1.81, 95% CI 1.19‐2.76) and posttransplant acute cellular allograft rejection (ACR) (OR 1.99, 95% 1.06‐3.75). Following the implementation of targeted antifungal prophylaxis in 2009, IA was identified in 2 of 107 (2.0%) patients in Cohort 2. Conclusions Increased pretransplant hospitalizations and posttransplant ACR episodes represent significant risk factors for IA following cardiac transplant. Targeted antifungal prophylaxis in at‐risk patients reduces the incidence of IA.
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.13367