Depressive, inflammatory, and metabolic factors associated with cognitive impairment in patients with epilepsy

The purpose of this study was to examine the cognitive function and depressive traits most frequently associated with the clinical assessment of patients with epilepsy and if these clinical parameters are linked to glycolipid levels and inflammatory and apoptotic markers. Patients with epilepsy (n =...

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Bibliographic Details
Published in:Epilepsy & behavior 2018-09, Vol.86, p.49-57
Main Authors: Arend, Josi, Kegler, Aline, Caprara, Ana Letícia Fornari, Almeida, Camila, Gabbi, Patricia, Pascotini, Eduardo T., de Freitas, Lori Ane Vargas, Miraglia, Cinara, Bertazzo, Taíse Leitemperger, Palma, Raphael, Arceno, Patrícia, Duarte, Marta M.M.F., Furian, Ana Flavia, Oliveira, Mauro Schneider, Royes, Luiz Fernando Freire, Mathern, Gary W., Fighera, Michele Rechia
Format: Article
Language:English
Subjects:
Adult
Aged
Apoptosis - physiology
Attention - physiology
Biomarkers - metabolism
Case-Control Studies
Caspase
Caspase 3
Cognition - physiology
Cognitive Dysfunction
Cytokines - blood
Depression
Depression - epidemiology
DNA damage
DNA Damage - physiology
Epilepsy
Epilepsy - metabolism
Epilepsy - pathology
Epilepsy - psychology
Executive Function - physiology
Female
Glucose
Humans
Inflammation
Inflammation - metabolism
Inflammation Mediators - metabolism
Lipids
Lipoproteins - blood
Male
Middle Aged
Neuropsychological profile
Neuropsychological Tests
Organic Chemicals
Triglycerides - blood
Tumor Necrosis Factor-alpha - blood
Young Adult
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Summary:The purpose of this study was to examine the cognitive function and depressive traits most frequently associated with the clinical assessment of patients with epilepsy and if these clinical parameters are linked to glycolipid levels and inflammatory and apoptotic markers. Patients with epilepsy (n = 32) and healthy subjects (n = 41) were recruited to participate in this study. Neuropsychological evaluation was performed in both groups through a battery of cognitive tests. Inflammatory markers, apoptotic factors, and deoxyribonucleic acid (DNA) damage were measured in blood samples. Additionally, the metabolic markers total cholesterol (CHO), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and glucose (GLU) levels were analyzed. Statistical analyses showed that patients with epilepsy presented decreased scores in memory, attention, language, and executive function tests compared with the control group. Analysis revealed that there was negative correlation in epilepsy for seizure duration vs. oral language (R = −0.4484, p 
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2018.07.007