Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome – A prospective observational study

The main purpose of this study was to determine the prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome (PCOS) and to explore the association of hypovitaminosis D with metabolic syndrome in women with PCOS. A prospective observational study was conducted in a terti...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2018-10, Vol.229, p.15-19
Main Authors: Mogili, Krishna Deepti, Karuppusami, Reka, Thomas, Sumi, Chandy, Achamma, Kamath, Mohan S, TK, Aleyamma
Format: Article
Language:English
Subjects:
Adult
Female
Humans
Hypovitaminosis D
India - epidemiology
Infertility, Female - etiology
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Polycystic ovarian syndrome
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - epidemiology
Prevalence
Prospective Studies
Vitamin D
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
Young Adult
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Summary:The main purpose of this study was to determine the prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome (PCOS) and to explore the association of hypovitaminosis D with metabolic syndrome in women with PCOS. A prospective observational study was conducted in a tertiary care, infertility centre from March 2016 to March 2017. The primary outcome was estimation of the prevalence of vitamin D deficiency in infertile PCOS women. Secondary outcomes were to study the association of hypovitaminosis D with metabolic syndrome, obesity and hypercholesterolemia in PCOS patients. A total of 256 infertile women with PCOS were included in the study. Vitamin D deficiency was observed in 70.3% women, 20.3% were vitamin D insufficient and only 9.4% were vitamin D sufficient. Metabolic syndrome was seen in 80/256 (31.25%) women. There was no evidence of an association between hypovitaminosis D and metabolic syndrome, obesity or hyperlipidemia. There was a strong evidence of an association between waist circumference of >80 cm and vitamin D deficiency (p = 0.02). Vitamin D deficiency is highly prevalent in infertile PCOS women and there seems to be no association between hypovitaminosis D and the metabolic syndrome in the same population.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2018.08.001