Clinical efficacy of the Toll-like receptor 9 agonist cobitolimod using patient-reported-outcomes defined clinical endpoints in patients with ulcerative colitis

The Toll-like-receptor 9 (TLR-9) agonist cobitolimod (DIMS0150, Kappaproct®) is a promising therapeutic option for ulcerative colitis (UC) patients. The objectives of this post-hoc analysis using the COLLECT study data was to investigate the clinical effects of cobitolimod using patient-reported-out...

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Bibliographic Details
Published in:Digestive and liver disease 2018-10, Vol.50 (10), p.1019-1029
Main Authors: Atreya, Raja, Reinisch, Walter, Peyrin-Biroulet, Laurent, Scaldaferri, Franco, Admyre, Charlotte, Knittel, Thomas, Kowalski, Jan, Neurath, Markus Friedrich, Hawkey, Christopher
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Aged
Colitis, Ulcerative - drug therapy
DNA - administration & dosage
Female
Humans
Internationality
Logistic Models
Male
Middle Aged
Multivariate Analysis
Patient Reported Outcome Measures
Retrospective Studies
Severity of Illness Index
Therapy
TLR-9
Toll-Like Receptor 9 - agonists
Toll-like receptor-9
Treatment Outcome
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Ulcerative colitis
Young Adult
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Summary:The Toll-like-receptor 9 (TLR-9) agonist cobitolimod (DIMS0150, Kappaproct®) is a promising therapeutic option for ulcerative colitis (UC) patients. The objectives of this post-hoc analysis using the COLLECT study data was to investigate the clinical effects of cobitolimod using patient-reported-outcomes (PRO) defined endpoints. Dual topical administration of cobitolimod was studied in a randomised, multicentre clinical trial named COLLECT in moderate-to-severe UC patients. Symptomatic remission (SR) was studied in 104 patients based on their e-diary records and was defined as absence of blood in stool and a mean daily stool frequency (SF) 
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2018.06.010