Patient survival on haemodiafiltration and haemodialysis: a cohort study using the Australia and New Zealand Dialysis and Transplant Registry

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 2019-02, Vol.34 (2), p.326-338
• Main Authors: See, Emily J, Hedley, James, Agar, John W M, Hawley, Carmel M, Johnson, David W, Kelly, Patrick J, Lee, Vincent W, Mac, Kathy, Polkinghorne, Kevan R, Rabindranath, Kannaiyan S, Sud, Kamal, Webster, Angela C
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Australia - epidemiology; Cohort Studies; Comorbidity; Female; Hemodiafiltration - mortality; Humans; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Kidney Transplantation - mortality; Male; Middle Aged; New Zealand - epidemiology; Peritoneal Dialysis - mortality; Proportional Hazards Models; Registries; Renal Dialysis - mortality; Time Factors; Young Adult
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfy209

Abstract Background It is unclear if haemodiafiltration improves patient survival compared with standard haemodialysis. Observational studies have tended to show benefit with haemodiafiltration, while meta-analyses have not provided definitive proof of superiority. Methods Using data from the Australia and New Zealand Dialysis and Transplant Registry, this binational inception cohort study compared all adult patients who commenced haemodialysis in Australia and New Zealand between 2000 and 2014. The primary outcome was all-cause mortality. Cardiovascular mortality was the secondary outcome. Outcomes were measured from the first haemodialysis treatment and were examined using multivariable Cox regression analyses. Patients were censored at permanent discontinuation of haemodialysis or at 31 December 2014. Analyses were stratified by country. Results The study included 26 961 patients (4110 haemodiafiltration, 22 851 standard haemodialysis; 22 774 Australia, 4187 New Zealand) with a median follow-up of 5.31 (interquartile range 2.87–8.36) years. Median age was 62 years, 61% were male, 71% were Caucasian. Compared with standard haemodialysis, haemodiafiltration was associated with a significantly lower risk of all-cause mortality [adjusted hazard ratio (HR) for Australia 0.79, 95% confidence interval (95% CI) 0.72–0.87; adjusted HR for New Zealand 0.88, 95% CI 0.78–1.00]. In Australian patients, there was also an association between haemodiafiltration and reduced cardiovascular mortality (adjusted HR 0.78, 95% CI 0.64–0.95). Conclusion Haemodiafiltration was associated with superior survival across patient subgroups of age, sex and comorbidity.