Kidney Nephron Determination

The nephron is a multifunctional filtration device equipped with an array of sophisticated sensors. For appropriate physiological function in the human and mouse, nephrons must be stereotypically arrayed in large numbers, and this essential structural property that defines the kidney is determined d...

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Bibliographic Details
Published in:Annual review of cell and developmental biology 2018-10, Vol.34 (1), p.427-450
Main Author: Oxburgh, Leif
Format: Article
Language:English
Subjects:
cap mesenchyme
Cell Differentiation - genetics
Fetal Development - genetics
Humans
Intercellular Signaling Peptides and Proteins - genetics
Kidney - growth & development
Kidney - metabolism
mesenchyme-to-epithelium transition
nephrogenesis
nephron differentiation
nephron progenitor cell
Nephrons - growth & development
Nephrons - metabolism
organogenesis
Organogenesis - genetics
Signal Transduction - genetics
Stem Cells - cytology
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Summary:The nephron is a multifunctional filtration device equipped with an array of sophisticated sensors. For appropriate physiological function in the human and mouse, nephrons must be stereotypically arrayed in large numbers, and this essential structural property that defines the kidney is determined during its fetal development. This review explores the process of nephron determination in the fetal kidney, providing an overview of the foundational literature in the field as well as exploring new developments in this dynamic research area. Mechanisms that ensure that a large number of nephrons can be formed from a small initial number of progenitor cells are central to this process, and the question of how the nephron progenitor cell population balances epithelial differentiation with renewal in the progenitor state is a subject of particular interest. Key growth factor signaling pathways and transcription factor networks are discussed.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev-cellbio-100616-060647