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The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study
•Gestational diabetes associated with an increased risk of postpartum depression.•Third-trimester depression did not mediate the above association.•First-trimester depression and gestational diabetes were not associated. The literature suggests an association between type 2 diabetes mellitus and dep...
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Published in: | Journal of affective disorders 2018-12, Vol.241, p.263-268 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Gestational diabetes associated with an increased risk of postpartum depression.•Third-trimester depression did not mediate the above association.•First-trimester depression and gestational diabetes were not associated.
The literature suggests an association between type 2 diabetes mellitus and depression, but data on the association between gestational diabetes mellitus (GDM) and postpartum depressive symptomatology (PPDS) are scarce.
Altogether, 1066 women with no previous mental health issues enrolled in the Kuopio Birth Cohort (KuBiCo, www.kubico.fi) were selected for this study. GDM was diagnosed according to the Finnish Current Care Guidelines. Depressive symptomatology was assessed with the Edinburgh Postnatal Depression Scale (EPDS) during the third trimester of pregnancy and eight weeks after delivery. Additionally, a subgroup of women (n = 505) also completed the EPDS during the first trimester of pregnancy.
The prevalence rates of GDM and PPDS in the whole study population were 14.1% and 10.3%, respectively. GDM was associated with an increased likelihood of belonging to the PPDS group (OR 2.23, 95% CI 1.23–4.05; adjusted for maternal age at delivery, BMI in the first trimester, smoking before pregnancy, relationship status, nulliparity, delivery by caesarean section, gestational age at delivery, neonatal intensive care unit admission and third-trimester EPDS scores). A significant association between GDM and PPDS was found in the subgroup of women with available data on first-trimester depression (n = 505).
The participation rate of the KuBiCo study was relatively low (37%).
Women with GDM may be at increased risk of PPDS. Future studies should investigate whether these women would benefit from a closer follow-up and possible supportive interventions during pregnancy and the postpartum period to avoid PPDS. |
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ISSN: | 0165-0327 1573-2517 |
DOI: | 10.1016/j.jad.2018.08.070 |