Relationship Between Central Venous Catheter Protein Adsorption and Water Infused Surface Protection Mechanisms

Central venous catheters (CVCs) are implanted in the majority of dialysis patients despite increased patient risk due to thrombotic occlusion and biofilm formation. Current solutions remain ineffective at preventing these complications and treatment options are limited and often harmful. We present...

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Bibliographic Details
Published in:Artificial organs 2018-11, Vol.42 (11), p.E369-E379
Main Authors: Sutherland, David W., Blanks, Zachary D., Zhang, Xin, Charest, Joseph L.
Format: Article
Language:English
Subjects:
Adsorption
Anticoagulants - chemistry
Biofilm
Biofilms
Blood flow
Blood Proteins - isolation & purification
Boundary layer
Boundary layers
Catheterization, Central Venous - adverse effects
Catheters
Central venous catheter
Central Venous Catheters - adverse effects
Complications
Dialysis
Drug delivery
Drug delivery systems
Fibrin sheath
Flow velocity
Free boundaries
Hemodialysis
Heparin
Heparin - chemistry
Hollow fiber membrane
Hollow fiber membranes
Humans
Medical instruments
Occlusion
Patients
Protein adsorption
Proteins
Saline solutions
Sheaths
Shedding
Surface chemistry
Surface Properties
Technology
Thrombosis
Thrombosis - etiology
Thrombosis - prevention & control
Vascular access
Venous access
Water - chemistry
Water infused surface protection
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Summary:Central venous catheters (CVCs) are implanted in the majority of dialysis patients despite increased patient risk due to thrombotic occlusion and biofilm formation. Current solutions remain ineffective at preventing these complications and treatment options are limited and often harmful. We present further analysis of the previously proposed water infused surface protection (WISP) technology, an active method to reduce protein adsorption and effectively disrupt adsorbed protein sheaths on the inner surface of CVCs. A WISP CVC is modeled by a hollow fiber membrane (HFM) in a benchtop device which continuously infuses a saline solution across the membrane wall into the blood flow, creating a blood‐free boundary layer at the lumen surface. Total protein adsorption is measured under various experimental conditions to further test WISP performance. The WISP device shows reduced protein adsorption as blood and WISP flow rates increase (P 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.13274