Serum uric acid potentially links metabolic health to measures of fuel use in lean and obese individuals

Uric acid (UA) is a byproduct of the high-energy purine metabolism and is conventionally regarded as a marker of cardio-metabolic impairment. Its potential relationship with energy homeostasis is unknown to date. In a cross-sectional study on 121 otherwise healthy obese and 99 sex- and-age-matched l...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2018-10, Vol.28 (10), p.1029-1035
Main Authors: Mele, C., Tagliaferri, M.A., Saraceno, G., Mai, S., Vietti, R., Zavattaro, M., Aimaretti, G., Scacchi, M., Marzullo, P.
Format: Article
Language:English
Subjects:
Adiposity
Adolescent
Adult
Biomarkers - blood
Calorimetry, Indirect
Cross-Sectional Studies
Electric Impedance
Energy Metabolism
Female
Humans
Male
Middle Aged
Obesity
Obesity - blood
Obesity - diagnosis
Obesity - physiopathology
Respiratory quotient
Resting energy expenditure
Retrospective Studies
Uric acid
Uric Acid - blood
Young Adult
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Summary:Uric acid (UA) is a byproduct of the high-energy purine metabolism and is conventionally regarded as a marker of cardio-metabolic impairment. Its potential relationship with energy homeostasis is unknown to date. In a cross-sectional study on 121 otherwise healthy obese and 99 sex- and-age-matched lean subjects, UA levels were analyzed in relation to metabolic health, inflammatory markers, respiratory quotient (RQ) and resting energy expenditure (REE) as assessed by indirect calorimetry, fat mass (%FM) and fat-free mass (FFM) as determined by bioimpedance analysis. As expected, obese and lean subjects differed in BMI, glucolipid homeostasis, leptin and insulin levels, inflammatory markers, %FM and FFM (p 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2018.06.010