Facing up to the global challenges of ageing

Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to ma...

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Bibliographic Details
Published in:Nature (London) 2018-09, Vol.561 (7721), p.45-56
Main Authors: Partridge, Linda, Deelen, Joris, Slagboom, P. Eline
Format: Article
Language:English
Subjects:
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692/700
Age
Aged
Aging
Aging - genetics
Aging - physiology
Animal cognition
Animals
Biomarkers
Cardiovascular disease
Cellular Senescence
Disabled Persons - statistics & numerical data
DNA methylation
Electronic Health Records
Electronic medical records
Food intake
Frailty
Genome-Wide Association Study
Genomes
Health risks
Humanities and Social Sciences
Humans
Internationality
Intestinal microflora
Laboratory animals
Life expectancy
Life Style
Lifestyles
Longevity - genetics
Microbiota
Models, Animal
Morbidity
Mortality
multidisciplinary
Netherlands - epidemiology
Older people
Phenotype
Population
Review Article
Science
Science (multidisciplinary)
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Summary:Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals and drugs can all improve late-life health in animals. Application to humans will require better biomarkers of disease risk and responses to interventions, closer alignment of work in animals and humans, and increased use of electronic health records, biobank resources and cohort studies. Longer human lives have led to a global burden of late-life disease, and so interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health.
ISSN:0028-0836
1476-4687
DOI:10.1038/s41586-018-0457-8