Early low molecular weight heparin for postpartum hemorrhage in women with pre-eclampsia. Is it effective to prevent consumptive coagulopathy?

• Published in: The journal of maternal-fetal & neonatal medicine 2020-02, Vol.33 (3), p.410-414
• Main Authors: Kilicci, Cetin, Ozkaya, Enis, Karakus, Resul, Sanverdi, Ilhan, Abide Yayla, Cigdem, Bostanci Ergen, Evrim, Mutlu, Sibel
• Format: Article
• Language: English
• Subjects: Disseminated intravascular coagulation; low molecular weight heparin; postpartum hemorrhage; pre-eclampsia
• ISSN: 1476-7058; 1476-4954
• DOI: 10.1080/14767058.2018.1494708

Background: Postpartum hemorrhage has been one of the most common cause of maternal morbidity and mortality. An association between pre-eclampsia (PE) and postpartum hemorrhage has been shown in previous studies. The aim of this study was to compare some characteristics of postpartum hemorrhage between women with and without PE. Methods: Some characteristics of postpartum hemorrhage were compared between women with (n = 34) and without PE (n = 34). Majority of the cases underwent low molecular heparin administration at postpartum eighth hour, however, in cases who did not give satisfactory responses to blood product transfusions, to block suspected disseminated intravascular coagulation (DIC) secondary to the PE induced vascular injury, low molecular weight heparins were started within 2 h of postpartum hemorrhage. Some characteristics of cases with and without PE and with and without early low molecular weight heparin administration were compared. Results: There were five cases who needed massive transfusions in group with PE, conversely, no case required massive transfusion in group without PE (p