Reduced colonic smooth muscle cholinergic responsiveness is associated with impaired bowel motility after chronic experimental high-level spinal cord injury

The mechanisms underlying bowel dysfunction after high-level spinal cord injury (SCI) are poorly understood. However, impaired supraspinal sympathetic and parasympathetic control is likely a major contributing factor. Disruption of the descending autonomic pathways traversing the spinal cord was ach...

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Bibliographic Details
Published in:Autonomic neuroscience 2019-01, Vol.216, p.33-38
Main Authors: Frias, B., Phillips, A.A., Squair, J.W., Lee, A.H.X., Laher, I., Krassioukov, A.V.
Format: Article
Language:English
Subjects:
Animals
Bowel
Colon
Colon - physiopathology
Digestion
Gastrointestinal Motility - physiology
Gastrointestinal Transit - physiology
Male
Muscle, Smooth - physiopathology
Rats
Receptor, Muscarinic M3 - physiology
Spinal Cord Injuries - physiopathology
Spinal cord injury
Time Factors
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Summary:The mechanisms underlying bowel dysfunction after high-level spinal cord injury (SCI) are poorly understood. However, impaired supraspinal sympathetic and parasympathetic control is likely a major contributing factor. Disruption of the descending autonomic pathways traversing the spinal cord was achieved by a T3 complete spinal cord transection, and colonic function was examined in vivo and ex vivo four weeks post-injury. Total gastrointestinal transit time (TGTT) was reduced and contractility of the proximal and distal colon was impaired due to reduced M3 receptor sensitivity. These data describe a clinically relevant model of bowel dysfunction after SCI.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2018.08.005