Change of skeletal muscle mass in patients with pheochromocytoma

The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance an...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2019-07, Vol.37 (4), p.694-702
Main Authors: Lee, Seung Hun, Kwak, Mi Kyung, Ahn, Seong Hee, Kim, Hyeonmok, Cho, Yoon Young, Suh, Sunghwan, Song, Kee-Ho, Koh, Jung-Min, Kim, Jae Hyeon, Kim, Beom-Jun
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - pathology
Adrenal Gland Neoplasms - urine
Body composition
Body fat
Catecholamines
Female
Humans
Linear Models
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolites
Metanephrine - urine
Middle Aged
Muscle, Skeletal - pathology
Musculoskeletal system
Normetanephrine - urine
Odds Ratio
Organ Size
Original Article
Orthopedics
Pheochromocytoma
Pheochromocytoma - pathology
Pheochromocytoma - urine
Sarcopenia
Skeletal muscle
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Summary:The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary metanephrine (UM), and urinary normetanephrine (UNM) were measured in 16 patients with pheochromocytoma and 224 patients with nonfunctioning adrenal incidentaloma (NFAI), we compared skeletal muscle mass and fat mass (FM) between the two groups. After adjustments for confounders, UM ( β  = − 0.171, P  = 0.006) and UNM ( β  = − 0.249, P  
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-018-0959-3