Human papillomavirus–associated oropharyngeal cancer among patients aged 70 and older: Dramatically increased prevalence and clinical implications

Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence among older adults. However, the role of human papillomavirus (HPV) in driving this trend and its prognostic significance in this population have not been established. The National Cancer Database was queried for patients with...

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Bibliographic Details
Published in:European journal of cancer (1990) 2018-11, Vol.103, p.195-204
Main Authors: Lu, Diana J., Luu, Michael, Mita, Alain, Scher, Kevin, Shiao, Stephen L., Yoshida, Emi P., Sittig, Mark P., Mallen-St Clair, Jon, Ho, Allen S., Zumsteg, Zachary S.
Format: Article
Language:English
Subjects:
Adults
Age
Aged
Aged, 80 and over
Cancer
Confidence intervals
Elderly
Epidemiology
Female
Geriatric
Geriatrics
HPV
Human papillomavirus
Humans
Male
Medical prognosis
Older people
Oropharyngeal cancer
Oropharyngeal Neoplasms - microbiology
Oropharynx cancer
Papillomaviridae - pathogenicity
Patients
Prevalence
Radiation
Radiation therapy
Squamous cell carcinoma
Surgery
Survival
Throat
Throat cancer
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Summary:Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence among older adults. However, the role of human papillomavirus (HPV) in driving this trend and its prognostic significance in this population have not been established. The National Cancer Database was queried for patients with OPSCC diagnosed from 2010 to 2015 undergoing either surgery or radiotherapy (RT) with known HPV status. Older adults were defined as those aged 70 years or older. Among 43,427 OPSCC patients, the proportion of HPV-positive OPSCC increased from 45.1% to 63.3% in older adults (P 
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2018.08.015