P(v-a)CO2/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: A prospective multicenter randomized controlled clinical study

The present study examined the value of P(v-a)CO2/C(a-v)O2 compared with ScvO2 as a target for clinical resuscitation of severe sepsis/septic shock. 228 patients were randomly divided into a P(v-a)CO2/C(a-v)O2-targeted and a ScvO2-targeted therapy group. The effects on hemodynamics, interventional i...

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Published in:Journal of critical care 2018-12, Vol.48, p.314-320
Main Authors: Su, Longxiang, Tang, Bo, Liu, Yaling, Zhou, Guanhua, Guo, Qinghua, He, Wei, Wang, Chunmei, Zhuang, Haizhou, Jiang, Li, Qin, Long, Deng, Qun, Shuai, Weizheng, Zhang, Lina, Wang, Xiaomeng, Su, Jie, Ma, Siqing, Liu, Dawei, Long, Yun
Format: Article
Language:English
Subjects:
Blood
Carbon dioxide
Catheters
Clinical trials
Hemoglobin
Hypoxia
Intensive care
Medical prognosis
Metabolism
Mortality
Outcome
P(v-a)CO2/C(a-v)O2
Patients
Resuscitation
ScvO2
Sepsis
Ventilators
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Summary:The present study examined the value of P(v-a)CO2/C(a-v)O2 compared with ScvO2 as a target for clinical resuscitation of severe sepsis/septic shock. 228 patients were randomly divided into a P(v-a)CO2/C(a-v)O2-targeted and a ScvO2-targeted therapy group. The effects on hemodynamics, interventional intensity, and outcome were recorded and analyzed. The mean arterial pressure (MAP) of the P(v-a)CO2/C(a-v)O2-targeted therapy group was significantly higher at 3 h, 12 h, 24 h, and 3 days (P 
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2018.09.009