Rate of Sustained Virologic Response in Relation to Baseline Hepatitis C Virus (HCV) RNA Level and Rapid Virologic Clearance in Persons with Acute HCV Infection

Treatment of acute hepatitis C virus (HCV) infection leads to a sustained virologic response (SVR) in the vast majority of patients, although the clinical predictors of these favorable responses are not well understood. In chronic infection, the most potent predictor of a SVR is complete viral suppr...

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Bibliographic Details
Published in:The Journal of infectious diseases 2009-09, Vol.200 (6), p.877-881
Main Authors: McGovern, Barbara H., Nagami, Ellen H., Birch, Christopher E., Bowen, Melinda J., Reyor, Laura L., Chung, Raymond T., Kim, Arthur Y.
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Antivirals
Biological and medical sciences
Cohort Studies
Female
Fundamental and applied biological sciences. Psychology
Genotype
Genotypes
Health outcomes
Hepacivirus
Hepacivirus - drug effects
Hepacivirus - genetics
Hepatitis C
Hepatitis C - blood
Hepatitis C - drug therapy
Hepatitis C - virology
Hepatitis C virus
Human viral diseases
Humans
Infections
Infectious diseases
Interferon-alpha - administration & dosage
Interferon-alpha - therapeutic use
Interferons
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - therapeutic use
Recombinant Proteins
Ribavirin - administration & dosage
Ribavirin - therapeutic use
RNA
RNA, Viral - blood
Viral diseases
Viral hepatitis
Viremia
Viremia - drug therapy
Virology
VIRUSES
Young Adult
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Description
Summary:Treatment of acute hepatitis C virus (HCV) infection leads to a sustained virologic response (SVR) in the vast majority of patients, although the clinical predictors of these favorable responses are not well understood. In chronic infection, the most potent predictor of a SVR is complete viral suppression after 4 weeks of treatment, also known as a rapid virologic response (RVR). However, few patients with HCV genotype 1 infection and high-level viremia ever achieve this benchmark. In 2 separate cohorts of patients with acute HCV infection, we demonstrate that rapid virologic clearance and low-level viremia (HCV RNA level,
ISSN:0022-1899
1537-6613
DOI:10.1086/605444