Basal ganglia neuroprotection with anticonvulsants after energy stress: a comparative study

The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model provides a valuable paradigm of the energy deficiency disorders found in childhood. In such disorders, anticonvulsants may provide neuroprotection by modulating cellular energy consumption and by exerting favorable pleiotropic effec...

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Bibliographic Details
Published in:Metabolic brain disease 2009-09, Vol.24 (3), p.453-461
Main Authors: Arpin, S, Lagrue, E, Bodard, S, Chalon, S, Castelnau, P
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - pharmacology
Autoradiography
Basal Ganglia - drug effects
Basal Ganglia Diseases - metabolism
Basal Ganglia Diseases - pathology
Basal Ganglia Diseases - prevention & control
Biochemistry
Biomedical and Life Sciences
Biomedicine
Dopamine Plasma Membrane Transport Proteins - metabolism
Dose-Response Relationship, Drug
Energy Metabolism - drug effects
Male
Metabolic Diseases
Mice
Mice, Inbred C57BL
MPTP Poisoning - metabolism
MPTP Poisoning - pathology
MPTP Poisoning - prevention & control
Neostriatum - pathology
Neurology
Neuroprotective Agents
Neurosciences
Oncology
Original Paper
Triazines - pharmacology
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Summary:The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model provides a valuable paradigm of the energy deficiency disorders found in childhood. In such disorders, anticonvulsants may provide neuroprotection by modulating cellular energy consumption and by exerting favorable pleiotropic effects on neuronal survival. To verify such hypothesis, we tested the effects of levetiracetam, vigabatrin, gabapentine, pregabaline, tiagabine, clonazepam and lamotrigine on neuroprotection in the MPTP mouse model. The membrane dopamine transporter (DAT) density, which provides a reliable index of dopaminergic neurons survival in the basal ganglia, was assessed by semi-quantitative autoradiography of the striatum. Unlike all other anticonvulsants tested, lamotrigine provided a significant and dose-dependent neuroprotection in these experimental conditions. Lamotrigine, a widely used and well-tolerated molecule in children, could provide neuroprotection in various energy deficiency disorders.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-009-9144-7