Development of a Clinically Viable Heroin Vaccine

Heroin is a highly abused opioid and incurs a significant detriment to society worldwide. In an effort to expand the limited pharmacotherapy options for opioid use disorders, a heroin conjugate vaccine was developed through comprehensive evaluation of hapten structure, carrier protein, adjuvant and...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2017-06, Vol.139 (25), p.8601-8611
Main Authors: Bremer, Paul T, Schlosburg, Joel E, Banks, Matthew L, Steele, Floyd. F, Zhou, Bin, Poklis, Justin L, Janda, Kim D
Format: Article
Language:English
Subjects:
adjuvants
Adjuvants, Immunologic - chemistry
alum
antibodies
antiserum
cross reaction
Drug Design
haptens
Haptens - chemistry
Heroin
Immunity, Humoral
immunization
immunoglobulin G
Macaca mulatta
metabolites
mice
monkeys
narcotics
oligodeoxyribonucleotides
surface plasmon resonance
vaccines
Vaccines, Conjugate
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