Fast dissolving fillers in dry foam formulation

Dry foam technology was developed as alternative granulation technique to overcome insufficient oral bioavailability of poorly soluble and wettable active pharmaceutical ingredients (APIs). In recent studies the type of filler showed to have a distinct influence on dry foam morphology as well as dis...

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Bibliographic Details
Published in:Powder technology 2015-01, Vol.270, p.494-501
Main Authors: Dischinger, Angela, Page, Susanne, Kleinebudde, Peter
Format: Article
Language:English
Subjects:
bioavailability
Dry foam
Fast dissolving filler
fenofibrate
fluidized beds
foams
high performance liquid chromatography
indomethacin
ingredients
Initial dissolution rate
maltodextrins
mannitol
molecular weight
Poorly soluble API
powders
solubility
surface area
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