High Levels of Avenanthramides in Oat-Based Diet Further Suppress High Fat Diet-Induced Atherosclerosis in Ldlr–/– Mice

Oats, in addition to cholesterol-lowering properties, contain unique antioxidants called avenanthramides (Avns), which inhibit both inflammatory cytokines and adhesion molecules in endothelial cells in culture. This study evaluated the effects of Avns of oats on atherosclerosis in Ldlr–/– mice, one...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2018-01, Vol.66 (2), p.498-504
Main Authors: Thomas, Michael, Kim, Sharon, Guo, Weimin, Collins, F. William, Wise, Mitchell L, Meydani, Mohsen
Format: Article
Language:English
Subjects:
adhesion
animal models
Animals
antioxidants
atherosclerosis
Atherosclerosis - diet therapy
Atherosclerosis - etiology
Atherosclerosis - metabolism
Avena - chemistry
Avena - metabolism
avenanthramides
blood
cholesteremic effect
cholesterol
Cholesterol - metabolism
cytokines
diet
Diet, High-Fat - adverse effects
Dietary Fiber - metabolism
Dietary Supplements - analysis
endothelial cells
Humans
Male
Mice
oat bran
oats
ortho-Aminobenzoates - analysis
ortho-Aminobenzoates - metabolism
Plant Extracts - analysis
Plant Extracts - metabolism
Receptors, LDL - deficiency
Receptors, LDL - genetics
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