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Hypocalcaemia following laryngectomy: prevalence and risk factors
To establish the prevalence of hypocalcaemia following laryngectomy and demonstrate that total thyroidectomy is a risk factor. A retrospective cohort study was conducted that included all patients who underwent total laryngectomy from 1st January 2006 to 1st August 2017. Exclusion criteria were: pre...
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| Published in: | Journal of laryngology and otology 2018-11, Vol.132 (11), p.969-973 |
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| cites | cdi_FETCH-LOGICAL-c373t-77fa1585e250edcd74c4823a6c155aa0d18b14381e289d6b402163d8f919dd63 |
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| container_issue | 11 |
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| container_title | Journal of laryngology and otology |
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| creator | Harris, A S Prades, E Passant, C D Ingrams, D R |
| description | To establish the prevalence of hypocalcaemia following laryngectomy and demonstrate that total thyroidectomy is a risk factor.
A retrospective cohort study was conducted that included all patients who underwent total laryngectomy from 1st January 2006 to 1st August 2017. Exclusion criteria were: pre-operative calcium derangement, previous thyroid or parathyroid surgery, concurrent glossectomy, pharyngectomy, or oesophagectomy.
Ninety patients were included. Sixteen patients had early hypocalcaemia (18 per cent), seven had protracted hypocalcaemia (8 per cent) and six had permanent hypocalcaemia (10 per cent). Exact logistic regression values for hypocalcaemia following total thyroidectomy compared to other patients were: early hypocalcaemia, odds ratio = 15.5 (95 per cent confidence interval = 2.2-181.9; model p = 0.002); protracted hypocalcaemia, odds ratio = 13.3 (95 per cent confidence interval = 1.5-117.1; model p = 0.01); and permanent hypocalcaemia, odds ratio = 22.7 (95 per cent confidence interval = 1.9-376.5; model p = 0.005).
This is the largest study to investigate the prevalence of hypocalcaemia following laryngectomy and the first to include follow up of longer than three months. Total thyroidectomy significantly increased the risk of hypocalcaemia at all time frames and independent of other variables. |
| doi_str_mv | 10.1017/S0022215118001615 |
| format | article |
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A retrospective cohort study was conducted that included all patients who underwent total laryngectomy from 1st January 2006 to 1st August 2017. Exclusion criteria were: pre-operative calcium derangement, previous thyroid or parathyroid surgery, concurrent glossectomy, pharyngectomy, or oesophagectomy.
Ninety patients were included. Sixteen patients had early hypocalcaemia (18 per cent), seven had protracted hypocalcaemia (8 per cent) and six had permanent hypocalcaemia (10 per cent). Exact logistic regression values for hypocalcaemia following total thyroidectomy compared to other patients were: early hypocalcaemia, odds ratio = 15.5 (95 per cent confidence interval = 2.2-181.9; model p = 0.002); protracted hypocalcaemia, odds ratio = 13.3 (95 per cent confidence interval = 1.5-117.1; model p = 0.01); and permanent hypocalcaemia, odds ratio = 22.7 (95 per cent confidence interval = 1.9-376.5; model p = 0.005).
This is the largest study to investigate the prevalence of hypocalcaemia following laryngectomy and the first to include follow up of longer than three months. Total thyroidectomy significantly increased the risk of hypocalcaemia at all time frames and independent of other variables.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215118001615</identifier><identifier>PMID: 30305187</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Calcium ; Dissection ; Ethics ; Female ; Humans ; Hypocalcemia ; Hypocalcemia - epidemiology ; Hypocalcemia - etiology ; Laboratories ; Laryngeal cancer ; Laryngectomy - adverse effects ; Main Articles ; Male ; Medical research ; Middle Aged ; Odds Ratio ; Otolaryngology ; Parathyroid ; Patients ; Prevalence ; Radiation therapy ; Retrospective Studies ; Risk Factors ; Software ; Surgery ; Systematic review ; Thyroid ; Thyroid gland ; Thyroidectomy ; Thyroidectomy - adverse effects</subject><ispartof>Journal of laryngology and otology, 2018-11, Vol.132 (11), p.969-973</ispartof><rights>Copyright © JLO (1984) Limited, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-77fa1585e250edcd74c4823a6c155aa0d18b14381e289d6b402163d8f919dd63</citedby><cites>FETCH-LOGICAL-c373t-77fa1585e250edcd74c4823a6c155aa0d18b14381e289d6b402163d8f919dd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215118001615/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,72960</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30305187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, A S</creatorcontrib><creatorcontrib>Prades, E</creatorcontrib><creatorcontrib>Passant, C D</creatorcontrib><creatorcontrib>Ingrams, D R</creatorcontrib><title>Hypocalcaemia following laryngectomy: prevalence and risk factors</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>To establish the prevalence of hypocalcaemia following laryngectomy and demonstrate that total thyroidectomy is a risk factor.
A retrospective cohort study was conducted that included all patients who underwent total laryngectomy from 1st January 2006 to 1st August 2017. Exclusion criteria were: pre-operative calcium derangement, previous thyroid or parathyroid surgery, concurrent glossectomy, pharyngectomy, or oesophagectomy.
Ninety patients were included. Sixteen patients had early hypocalcaemia (18 per cent), seven had protracted hypocalcaemia (8 per cent) and six had permanent hypocalcaemia (10 per cent). Exact logistic regression values for hypocalcaemia following total thyroidectomy compared to other patients were: early hypocalcaemia, odds ratio = 15.5 (95 per cent confidence interval = 2.2-181.9; model p = 0.002); protracted hypocalcaemia, odds ratio = 13.3 (95 per cent confidence interval = 1.5-117.1; model p = 0.01); and permanent hypocalcaemia, odds ratio = 22.7 (95 per cent confidence interval = 1.9-376.5; model p = 0.005).
This is the largest study to investigate the prevalence of hypocalcaemia following laryngectomy and the first to include follow up of longer than three months. Total thyroidectomy significantly increased the risk of hypocalcaemia at all time frames and independent of other variables.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Calcium</subject><subject>Dissection</subject><subject>Ethics</subject><subject>Female</subject><subject>Humans</subject><subject>Hypocalcemia</subject><subject>Hypocalcemia - epidemiology</subject><subject>Hypocalcemia - etiology</subject><subject>Laboratories</subject><subject>Laryngeal cancer</subject><subject>Laryngectomy - adverse effects</subject><subject>Main Articles</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Otolaryngology</subject><subject>Parathyroid</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Software</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroidectomy</subject><subject>Thyroidectomy - adverse effects</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kEtPwzAQhC0EoqXwA7igSFy4BLx-xA63qgKKhMSB3iPHdqoU54HdgPrvcdUCEojTHubb2Z1B6BzwNWAQNy8YE0KAA0iMIQN-gMYgmEw5y_AhGm_ldKuP0EkIKxwhgckxGlFMMQcpxmg63_SdVk4r29QqqTrnuo-6XSZO-U27tHrdNZvbpPf2XTnbapuo1iS-Dq9JpaLowyk6qpQL9mw_J2hxf7eYzdOn54fH2fQp1VTQdSpEpYBLbgnH1mgjmGaSUJVp4FwpbECWwKgES2RuspJhAhk1ssohNyajE3S1s-199zbYsC6aOmjrnGptN4SCxBJiKCHyiF7-Qlfd4Nv4XKSYFEJyyiIFO0r7LgRvq6L3dRNTF4CLbb3Fn3rjzsXeeSgba743vvqMAN2bqqb0tVnan9v_234C612CcA</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Harris, A S</creator><creator>Prades, E</creator><creator>Passant, C D</creator><creator>Ingrams, D R</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201811</creationdate><title>Hypocalcaemia following laryngectomy: prevalence and risk factors</title><author>Harris, A S ; Prades, E ; Passant, C D ; Ingrams, D R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-77fa1585e250edcd74c4823a6c155aa0d18b14381e289d6b402163d8f919dd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Calcium</topic><topic>Dissection</topic><topic>Ethics</topic><topic>Female</topic><topic>Humans</topic><topic>Hypocalcemia</topic><topic>Hypocalcemia - epidemiology</topic><topic>Hypocalcemia - etiology</topic><topic>Laboratories</topic><topic>Laryngeal cancer</topic><topic>Laryngectomy - adverse effects</topic><topic>Main Articles</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Otolaryngology</topic><topic>Parathyroid</topic><topic>Patients</topic><topic>Prevalence</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Software</topic><topic>Surgery</topic><topic>Systematic review</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroidectomy</topic><topic>Thyroidectomy - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, A S</creatorcontrib><creatorcontrib>Prades, E</creatorcontrib><creatorcontrib>Passant, C D</creatorcontrib><creatorcontrib>Ingrams, D R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, A S</au><au>Prades, E</au><au>Passant, C D</au><au>Ingrams, D R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypocalcaemia following laryngectomy: prevalence and risk factors</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2018-11</date><risdate>2018</risdate><volume>132</volume><issue>11</issue><spage>969</spage><epage>973</epage><pages>969-973</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><abstract>To establish the prevalence of hypocalcaemia following laryngectomy and demonstrate that total thyroidectomy is a risk factor.
A retrospective cohort study was conducted that included all patients who underwent total laryngectomy from 1st January 2006 to 1st August 2017. Exclusion criteria were: pre-operative calcium derangement, previous thyroid or parathyroid surgery, concurrent glossectomy, pharyngectomy, or oesophagectomy.
Ninety patients were included. Sixteen patients had early hypocalcaemia (18 per cent), seven had protracted hypocalcaemia (8 per cent) and six had permanent hypocalcaemia (10 per cent). Exact logistic regression values for hypocalcaemia following total thyroidectomy compared to other patients were: early hypocalcaemia, odds ratio = 15.5 (95 per cent confidence interval = 2.2-181.9; model p = 0.002); protracted hypocalcaemia, odds ratio = 13.3 (95 per cent confidence interval = 1.5-117.1; model p = 0.01); and permanent hypocalcaemia, odds ratio = 22.7 (95 per cent confidence interval = 1.9-376.5; model p = 0.005).
This is the largest study to investigate the prevalence of hypocalcaemia following laryngectomy and the first to include follow up of longer than three months. Total thyroidectomy significantly increased the risk of hypocalcaemia at all time frames and independent of other variables.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>30305187</pmid><doi>10.1017/S0022215118001615</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0022-2151 |
| ispartof | Journal of laryngology and otology, 2018-11, Vol.132 (11), p.969-973 |
| issn | 0022-2151 1748-5460 |
| language | eng |
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| source | Cambridge University Press |
| subjects | Adult Aged Aged, 80 and over Calcium Dissection Ethics Female Humans Hypocalcemia Hypocalcemia - epidemiology Hypocalcemia - etiology Laboratories Laryngeal cancer Laryngectomy - adverse effects Main Articles Male Medical research Middle Aged Odds Ratio Otolaryngology Parathyroid Patients Prevalence Radiation therapy Retrospective Studies Risk Factors Software Surgery Systematic review Thyroid Thyroid gland Thyroidectomy Thyroidectomy - adverse effects |
| title | Hypocalcaemia following laryngectomy: prevalence and risk factors |
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