Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer

Background Galunisertib is the first-in-class, first-in-human, oral small-molecule type I transforming growth factor-beta receptor (ALK5) serine/threonine kinase inhibitor to enter clinical development. The effect of galunisertib vs. placebo in patients with unresectable pancreatic cancer was determ...

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Bibliographic Details
Published in:British journal of cancer 2018-11, Vol.119 (10), p.1208-1214
Main Authors: Melisi, Davide, Garcia-Carbonero, Rocio, Macarulla, Teresa, Pezet, Denis, Deplanque, Gael, Fuchs, Martin, Trojan, Jorg, Oettle, Helmut, Kozloff, Mark, Cleverly, Ann, Smith, Claire, Estrem, Shawn T., Gueorguieva, Ivelina, Lahn, Michael M. F., Blunt, Al, Benhadji, Karim A., Tabernero, Josep
Format: Article
Language:English
Subjects:
631/67/1059/2325
692/53/2422
692/53/2423
Adenocarcinoma
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bayesian analysis
Biomarkers
Biomarkers, Tumor - metabolism
Biomedical and Life Sciences
Biomedicine
Cancer Research
Chemotherapy
Clinical trials
Deoxycytidine - administration & dosage
Deoxycytidine - adverse effects
Deoxycytidine - analogs & derivatives
Deoxycytidine - pharmacokinetics
Deoxycytidine - therapeutic use
Dose-Response Relationship, Drug
Drug Resistance
Enzyme inhibitors
Epidemiology
Female
Gemcitabine
Humans
Inflammation
Macrophage inflammatory protein
Macrophage inflammatory protein 1
Male
Metastases
Middle Aged
Molecular Medicine
Monoclonal antibodies
Oncology
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - metabolism
Patients
Placebos
Protein-serine/threonine kinase
Pyrazoles - administration & dosage
Pyrazoles - adverse effects
Pyrazoles - pharmacokinetics
Pyrazoles - therapeutic use
Quinolines - administration & dosage
Quinolines - adverse effects
Quinolines - pharmacokinetics
Quinolines - therapeutic use
Signal Transduction
Targeted cancer therapy
Toxicity
Transforming Growth Factor beta - metabolism
Transforming growth factor-b
α-Interferon
γ-Interferon
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