Microstructural Damage in Normal-Appearing Brain Parenchyma and Neurocognitive Dysfunction in Adult Moyamoya Disease

BACKGROUND AND PURPOSE―Microstructural damage in the brain induced by chronic ischemia is suggested to play a pivotal role in the neurocognitive dysfunction of adults with Moyamoya disease (MMD). We investigated specific changes in the brain microstructure and their correlations with neurocognitive...

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Bibliographic Details
Published in:Stroke (1970) 2018-10, Vol.49 (10), p.2504-2507
Main Authors: Hara, Shoko, Hori, Masaaki, Murata, Syo, Ueda, Ryo, Tanaka, Yoji, Inaji, Motoki, Maehara, Taketoshi, Aoki, Shigeki, Nariai, Tadashi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Axons - pathology
Brain - pathology
Brain - surgery
Cognitive Dysfunction - pathology
Cognitive Dysfunction - surgery
Diffusion Magnetic Resonance Imaging - methods
Female
Humans
Male
Middle Aged
Moyamoya Disease - physiopathology
Moyamoya Disease - surgery
Neurites - pathology
Treatment Outcome
Young Adult
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Summary:BACKGROUND AND PURPOSE―Microstructural damage in the brain induced by chronic ischemia is suggested to play a pivotal role in the neurocognitive dysfunction of adults with Moyamoya disease (MMD). We investigated specific changes in the brain microstructure and their correlations with neurocognitive dysfunction in patients with MMD using a multishell diffusion magnetic resonance imaging technique called neurite orientation dispersion and density imaging. METHODS—We evaluated 26 patients with MMD (16–63 years old, 20 females) and 20 age- and sex-matched normal volunteers using neurite orientation dispersion and density imaging and neuropsychological batteries. Neurite orientation dispersion and density imaging calculates 2 parametersthe intracellular volume fraction (Vic), which reflects the axon density in the white matter and dendrite density in the cortex, and the orientation dispersion index (OD), which reflects the network complexity. The microstructural damage and its correlation with neurocognitive performance were evaluated by performing a whole-brain analysis using SPM12 and correlation analysis with regional values. RESULTS—Patients with MMD had significantly lower Vic in the white matter and a lower OD mainly in the cortex than those of the controls (P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.118.022367