Ruthenium-catalyzed C-H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

Ruthenium-catalysis enabled the C-5 selective C-H oxygenation of naphthoquinones, and also sets the stage for the site-selective introduction of a hydroxyl group into anthraquinones. A-ring modified naphthoquinoidal compounds represent an important class of bioactive quinones for which the present s...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (91), p.1284-12843
Main Authors: Dias, Gleiston G, Rogge, Torben, Kuniyil, Rositha, Jacob, Claus, Menna-Barreto, Rubem F. S, da Silva Júnior, Eufrânio N, Ackermann, Lutz
Format: Article
Language:English
Subjects:
Anthraquinones
Catalysis
Crystallography
Hydroxyl groups
Oxygenation
Quinones
Ruthenium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ruthenium-catalysis enabled the C-5 selective C-H oxygenation of naphthoquinones, and also sets the stage for the site-selective introduction of a hydroxyl group into anthraquinones. A-ring modified naphthoquinoidal compounds represent an important class of bioactive quinones for which the present study encompasses the first C-H oxygenation strategy by weak O-coordination. C-H oxygenation of quinones by weak O-coordination was achieved by versatile ruthenium( ii ) catalysis with ample substrate scope and trypanocidal compounds were also identified.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07572g