Assessment of prior opioid tolerance among new users of fentanyl transdermal system in FDA's Sentinel System

Purpose Fentanyl transdermal system (FTS) is intended only for patients with prior opioid tolerance. The purpose of this study is to identify the proportion of new FTS users who had evidence of prior opioid tolerance, by dosage strength, in FDA's Sentinel System. Methods We identified new FTS e...

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Bibliographic Details
Published in:Pharmacoepidemiology and drug safety 2019-01, Vol.28 (1), p.112-116
Main Authors: Cocoros, Noelle M., Larochelle, Marc R., Popovic, Jennifer, Petrone, Andrew B., Kornegay, Cynthia, Ju, Jing, Racoosin, Judith A.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Adolescent
Adult
analgesics
Analgesics, Opioid - administration & dosage
Child
Child, Preschool
Delayed-Action Preparations - administration & dosage
Dosage
Drug Tolerance
Drug Utilization Review - standards
Drug Utilization Review - statistics & numerical data
Female
Fentanyl
Fentanyl - administration & dosage
Humans
Infant
Infant, Newborn
Labeling
Male
Middle Aged
Narcotics
opioidfentanyl
Opioids
Oxycodone
Pain - drug therapy
pharmacoepidemiology
REMS
Risk Assessment - standards
Sentinel Surveillance
Sentinel system
Transdermal medication
Transdermal Patch
United States
United States Food and Drug Administration - standards
United States Food and Drug Administration - statistics & numerical data
Young Adult
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Summary:Purpose Fentanyl transdermal system (FTS) is intended only for patients with prior opioid tolerance. The purpose of this study is to identify the proportion of new FTS users who had evidence of prior opioid tolerance, by dosage strength, in FDA's Sentinel System. Methods We identified new FTS episodes (183‐day washout) from 2009 through 2013. Members were
ISSN:1053-8569
1099-1557
DOI:10.1002/pds.4677