Increase in chloride from baseline is independently associated with mortality in critically ill children

Purpose To determine if there is an association between mortality and admission chloride levels and/or increases in the chloride level in critically ill children. Methods We performed a retrospective cohort study of all patients admitted to the paediatric intensive care unit (PICU) from January 2014...

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Bibliographic Details
Published in:Intensive care medicine 2018-12, Vol.44 (12), p.2183-2191
Main Authors: Barhight, Matthew F., Brinton, John, Stidham, Timothy, Soranno, Danielle E., Faubel, Sarah, Griffin, Benjamin R., Goebel, Jens, Mourani, Peter M., Gist, Katja M.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - blood
Acute Kidney Injury - epidemiology
Adolescent
Age Factors
Anesthesiology
Child
Child, Preschool
Children
Chloride
Chloride transport
Chlorides - blood
Chronic kidney failure
Critical Care Medicine
Critical Illness - mortality
Diabetes mellitus
Diabetic ketoacidosis
Emergency Medicine
End-stage renal disease
Female
Health aspects
Hospital Mortality
Hospitalization
Humans
Infant
Intensive
Intensive care
Intensive Care Units, Pediatric
Ketoacidosis
Kidney diseases
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Mortality
Pain Medicine
Patients
Pediatric intensive care
Pediatric Original
Pediatrics
Pneumology/Respiratory System
Retrospective Studies
Risk analysis
Risk Factors
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Summary:Purpose To determine if there is an association between mortality and admission chloride levels and/or increases in the chloride level in critically ill children. Methods We performed a retrospective cohort study of all patients admitted to the paediatric intensive care unit (PICU) from January 2014 to December 2015. Patients were excluded for the following reasons: (1) age  18 years, (2) admission to the cardiac intensive care unit, (3) no laboratory values upon admission to the PICU, (4) history of end-stage renal disease, (5) a disorder of chloride transport, and (6) admission for diabetic ketoacidosis. The patients were stratified on the basis of admission chloride levels (hypochloraemia,
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-018-5424-1