Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: A super([31])P MRS brain imaging study

• Published in: Drug and alcohol dependence 2010-01, Vol.106 (2-3), p.79-91
• Main Authors: Trksak, George H, Jensen, JEric, Plante, David T, Penetar, David M, Tartarini, Wendy L, Maywalt, Melissa A, Brendel, Michael, Dorsey, Cynthia M, Renshaw, Perry F, Lukas, Scott E
• Format: Article
• Language: English
• ISSN: 0376-8716
• DOI: 10.1016/j.drugalcdep.2009.07.022

Insomnia afflicts many individuals, but particularly those in chronic methadone treatment. Studies examining sleep deprivation (SD) have begun to identify sleep restoration processes involving brain bioenergetics. The technique super([31])P magnetic resonance spectroscopy (MRS) can measure brain changes in the high-energy phosphates: alpha-, beta-, and gamma-nucleoside triphosphate (NTP). In the present study, 21 methadone-maintained (MM) and 16 control participants underwent baseline (BL), SD (40 wakeful hours), recovery1 (RE1), and recovery2 (RE2) study nights. Polysomnographic sleep was recorded each night and super([31])P MRS brain scanning conducted each morning using a 4T MR scanner (dual-tuned proton/phosphorus head-coil). Interestingly, increases in total sleep time (TST) and sleep efficiency index (SEI) commonly associated with RE sleep were not apparent in MM participants. Analysis of methadone treatment duration revealed that the lack of RE sleep increases in TST and SEI was primarily exhibited by short-term MM participants (methadone 12 months) participants was more comparable to control participants. Slow wave sleep increased during RE1, but there was no difference between MM and control participants. Spectral power analysis revealed that compared to control participants; MM participants had greater delta, theta, and alpha spectral power during BL and RE sleep. super([31])P MRS revealed that elevations in brain beta-NTP (a direct measure of ATP) following RE sleep were greater in MM compared to control participants. Results suggest that differences in sleep and brain chemistry during RE in MM participants may be reflective of a disruption in homeostatic sleep function.