Distribution of peripherally injected peptide YY ([125I] PYY (3-36)) and pancreatic polypeptide ([125I] hPP) in the CNS: enrichment in the area postrema

The mechanism by which blood-borne peptide YY (3-36) (PYY(3-36)) and pancreatic polypeptide (PP) inhibit food intake is not clear and could implicate peripheral (vagal afferent pathways) and/or central (direct action on specific brain nuclei) mechanisms. To identify the primary brain structure(s) th...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2007-11, Vol.33 (3), p.294-304
Main Authors: Dumont, Yvan, Moyse, Emmanuel, Fournier, Alain, Quirion, Rémi
Format: Article
Language:English
Subjects:
Animals
Area Postrema - cytology
Area Postrema - metabolism
Autoradiography
Eating
Humans
Iodine Radioisotopes - chemistry
Iodine Radioisotopes - metabolism
Male
Pancreatic Polypeptide - administration & dosage
Pancreatic Polypeptide - chemistry
Pancreatic Polypeptide - metabolism
Peptide Fragments
Peptide YY - administration & dosage
Peptide YY - chemistry
Peptide YY - metabolism
Polypeptides
Rats
Rats, Sprague-Dawley
Rodents
Tissue Distribution
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Summary:The mechanism by which blood-borne peptide YY (3-36) (PYY(3-36)) and pancreatic polypeptide (PP) inhibit food intake is not clear and could implicate peripheral (vagal afferent pathways) and/or central (direct action on specific brain nuclei) mechanisms. To identify the primary brain structure(s) that could be activated after a peripheral injection of neuropeptide Y-related peptides, we investigated the distribution of radioactive materials using whole body autoradiography and coronal brain sections. Rats were injected with [125I] porcine (p) PYY(3-36) (i.p., 10 microCi) and killed after 30 min, 1, 2, or 4 h. After i.p. administration, significant amounts of radioactive materials were rapidly (
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-007-9007-9