Intensive Versus Moderate Statin Therapy Discontinuation in Patients With Acute Ischemic Stroke or Transient Ischemic Attack

The differences of discontinuation risk between intensive and mild-to-moderate statin therapy in patients with acute ischemic stroke is not clear. This study aimed to clarify whether intensive statin therapy resulted in a significant increase in discontinuation early after discharge. This multicente...

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Bibliographic Details
Published in:Clinical therapeutics 2018-12, Vol.40 (12), p.2041-2049
Main Authors: Yuan, Huai Wu, Ji, Ren Jie, Lin, Ya Jie, Chen, Han Feng, Peng, Guo Ping, Luo, Ben Yan
Format: Article
Language:English
Subjects:
Angina pectoris
Atherosclerosis
Cardiac arrhythmia
Cardiology
Cholesterol
Clinical trials
Cognition & reasoning
Diabetes
Discharge
Disease
Etiology
Health risk assessment
Heart
Heart attacks
Hypertension
Ischemia
ischemic stroke
Laboratories
Medical research
Patients
Prevention
Risk
secondary prevention
statin intensity
Statins
Statistical analysis
Stroke
Subgroups
Therapy
therapy discontinuation
Transient ischemic attack
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Summary:The differences of discontinuation risk between intensive and mild-to-moderate statin therapy in patients with acute ischemic stroke is not clear. This study aimed to clarify whether intensive statin therapy resulted in a significant increase in discontinuation early after discharge. This multicenter registry study enrolled consecutive hospitalized patients with ischemic stroke or transient ischemic attack. All the patients were prescribed statin therapy at discharge. Intensity of statin therapy was defined according to the 2013 American College of Cardiology/American Heart Association guideline on the treatment of blood cholesterol. A logistic regression model was used to analyze the association between statin therapy intensity and discontinuation. This study included 505 patients, of whom 64 and 441 received intensive and moderate statin therapy, respectively (mean follow-up, approximately 6 months). The rates of discontinuation of intensive and moderate statin therapy were 31.3% and 10.7% (P 
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2018.10.003