Serotypes and genotypes of S. pneumoniae isolates from adult invasive disease in Spain: A 5-year prospective surveillance after pediatric PCV13 licensure. The ODIN study

Serotypes/genotypes causing invasive pneumococcal disease (IPD) in adults are determined by vaccination strategies. The aim of this study was to assess the epidemiology of IPD in adults (≥18 years) after PCV13 introduction for children: serotypes, clonal complexes, antibiotic non-susceptibility and...

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Bibliographic Details
Published in:Vaccine 2018-12, Vol.36 (52), p.7993-8000
Main Authors: Fenoll, Asunción, Ardanuy, Carmen, Liñares, Josefina, Cercenado, Emilia, Marco, Francesc, Fleites, Ana, Rodríguez-Mayo, María, López-Hontangas, Jose-Luis, Palop, Begoña, Aller, Ana-Isabel, Buendía, Buenaventura, Méndez, Cristina, Cifuentes, Isabel
Format: Article
Language:English
Subjects:
Adults
Antibiotics
Antimicrobial agents
Bacteremia
Children
Clonal complex
Cloning
Disease
Epidemiology
Erythromycin
Fluids
Genotypes
Immunization
Invasive pneumococcal disease
Laboratories
Levofloxacin
Meningitis
Patients
PCV13
Penicillin
Peritonitis
Pneumonia
Serotype
Serotypes
Streptococcus infections
Streptococcus pneumoniae
Surveillance
Trends
Vaccination
Vaccines
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Summary:Serotypes/genotypes causing invasive pneumococcal disease (IPD) in adults are determined by vaccination strategies. The aim of this study was to assess the epidemiology of IPD in adults (≥18 years) after PCV13 introduction for children: serotypes, clonal complexes, antibiotic non-susceptibility and clinical presentations. We performed a prospective, clinical surveillance of hospitalized culture-confirmed IPDs in adults in nine Spanish hospitals (August 2010–June 2015). A total of 1087 culture-confirmed IPD episodes were included, of which 772 (71.0%) had bacteremic pneumonia (401 complicated/371 uncomplicated pneumonia), 122 (11.2%) meningitis, 102 (9.4%) non-focal bacteremia, 34 (3.1%) peritonitis and 57 (5.3%) others. The most common serotypes were: 3 (12.7%), 19A (8.5%), 8 (7.7%), 7F (6.3%), 1 (4.2%), 6C (4.2%), 11A (4.2%), 22F (4.2%) and 14 (4.0%). Vaccine types (PCV13 + 6C) caused 49.8% of IPD episodes, with a significant decrease over the 5-year period, and significant decreases in serotypes 6C and 7F. The most common genotypes were: CC180 (8.4%), CC191 (6.0%), and CC53 (5.0%). Vaccine types caused 53.9% (414/768) pneumonia episodes and 58.9% (235/399) complicated pneumonia, 53.4% IPD in adults
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2018.10.098