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Gender differences in homocysteine concentrations, a population-based cross-sectional study
High concentrations of homocysteine are considered a risk factor for atherosclerosis and coronary artery disease. The aim of this study was to assess whether or not there are gender differences in the plasma concentrations of homocysteine. Data were collected from medical records of individuals exam...
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| Published in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2019-01, Vol.29 (1), p.9-14 |
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| container_title | Nutrition, metabolism, and cardiovascular diseases |
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| creator | Cohen, E. Margalit, I. Shochat, T. Goldberg, E. Krause, I. |
| description | High concentrations of homocysteine are considered a risk factor for atherosclerosis and coronary artery disease. The aim of this study was to assess whether or not there are gender differences in the plasma concentrations of homocysteine.
Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000–2014. Cross sectional analysis was carried out on 9237 men and 4353 women. Mean (SD) age of the study sample was 48.4 (9.7) and 47.7 (9.7) years for men and women respectively. Average homocysteine concentrations were 12.6 (5.9) and 9.6 (3.2) μmol/L in men and women respectively (p |
| doi_str_mv | 10.1016/j.numecd.2018.09.003 |
| format | article |
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Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000–2014. Cross sectional analysis was carried out on 9237 men and 4353 women. Mean (SD) age of the study sample was 48.4 (9.7) and 47.7 (9.7) years for men and women respectively. Average homocysteine concentrations were 12.6 (5.9) and 9.6 (3.2) μmol/L in men and women respectively (p < 0.001). Prevalence of homocysteine concentrations above 15 μmol/L was found to be significantly higher in men than in women; 15.5% vs 3.9% respectively (p < 0.001). Low concentrations of vitamin (B12 < 200 pmol/L) and low concentrations of folate (<12 nmol/L) were found to be significantly higher in men than in women 20.4% vs. 16.0% and 18.5% vs. 10.8% respectively. Compared to women, men had a significantly higher odds ratio (95% CI) of having homocysteine concentrations above 15 μmol/L: non adjusted model, 4.47 (3.80–5.26); adjusted model for age, smoking status, body mass index, diabetes mellitus, kidney function and low serum concentrations of vitamin B12 and folate, 3.44 (2.89–4.09).
Plasma homocysteine concentrations are higher in men than in women. This may be a contributing factor to gender differences for developing atherosclerosis and coronary artery disease.
•High levels of homocysteine are considered a risk factor for atherosclerosis.•Data on gender differences and homocysteine levels are scarce.•The current study assessed homocysteine gender differences in 13,590 subjects.•Both plasma homocysteine concentrations and prevalence of hyperhomocysteinemia were higher in men.•Hyperhomocysteinemia is another gender difference in the risk of atherosclerosis.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2018.09.003</identifier><identifier>PMID: 30459075</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Atherosclerosis - blood ; Atherosclerosis - epidemiology ; Biomarkers - blood ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - epidemiology ; Cross-Sectional Studies ; Female ; Folate ; Folic Acid Deficiency - blood ; Folic Acid Deficiency - epidemiology ; Gender ; Homocysteine ; Homocysteine - blood ; Humans ; Hyperhomocysteinemia - blood ; Hyperhomocysteinemia - diagnosis ; Hyperhomocysteinemia - epidemiology ; Israel ; Male ; Middle Aged ; Prevalence ; Prognosis ; Risk Factors ; Sex Factors ; Vitamin B 12 Deficiency - blood ; Vitamin B 12 Deficiency - epidemiology ; Vitamin B12 ; Young Adult</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2019-01, Vol.29 (1), p.9-14</ispartof><rights>2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-66cd092ebe92617150de065ab23246eb9d0c8693f7856918f78dc71ba7b97fe93</citedby><cites>FETCH-LOGICAL-c428t-66cd092ebe92617150de065ab23246eb9d0c8693f7856918f78dc71ba7b97fe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30459075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, E.</creatorcontrib><creatorcontrib>Margalit, I.</creatorcontrib><creatorcontrib>Shochat, T.</creatorcontrib><creatorcontrib>Goldberg, E.</creatorcontrib><creatorcontrib>Krause, I.</creatorcontrib><title>Gender differences in homocysteine concentrations, a population-based cross-sectional study</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>High concentrations of homocysteine are considered a risk factor for atherosclerosis and coronary artery disease. The aim of this study was to assess whether or not there are gender differences in the plasma concentrations of homocysteine.
Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000–2014. Cross sectional analysis was carried out on 9237 men and 4353 women. Mean (SD) age of the study sample was 48.4 (9.7) and 47.7 (9.7) years for men and women respectively. Average homocysteine concentrations were 12.6 (5.9) and 9.6 (3.2) μmol/L in men and women respectively (p < 0.001). Prevalence of homocysteine concentrations above 15 μmol/L was found to be significantly higher in men than in women; 15.5% vs 3.9% respectively (p < 0.001). Low concentrations of vitamin (B12 < 200 pmol/L) and low concentrations of folate (<12 nmol/L) were found to be significantly higher in men than in women 20.4% vs. 16.0% and 18.5% vs. 10.8% respectively. Compared to women, men had a significantly higher odds ratio (95% CI) of having homocysteine concentrations above 15 μmol/L: non adjusted model, 4.47 (3.80–5.26); adjusted model for age, smoking status, body mass index, diabetes mellitus, kidney function and low serum concentrations of vitamin B12 and folate, 3.44 (2.89–4.09).
Plasma homocysteine concentrations are higher in men than in women. This may be a contributing factor to gender differences for developing atherosclerosis and coronary artery disease.
•High levels of homocysteine are considered a risk factor for atherosclerosis.•Data on gender differences and homocysteine levels are scarce.•The current study assessed homocysteine gender differences in 13,590 subjects.•Both plasma homocysteine concentrations and prevalence of hyperhomocysteinemia were higher in men.•Hyperhomocysteinemia is another gender difference in the risk of atherosclerosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - epidemiology</subject><subject>Biomarkers - blood</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Folate</subject><subject>Folic Acid Deficiency - blood</subject><subject>Folic Acid Deficiency - epidemiology</subject><subject>Gender</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - blood</subject><subject>Hyperhomocysteinemia - diagnosis</subject><subject>Hyperhomocysteinemia - epidemiology</subject><subject>Israel</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Vitamin B 12 Deficiency - blood</subject><subject>Vitamin B 12 Deficiency - epidemiology</subject><subject>Vitamin B12</subject><subject>Young Adult</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAQgIMouj7-gUiPHmxNmiZpLoKIrsKCFz15CGkyxSxtsyatsP_e1FWPnoYZvnl9CJ0TXBBM-PW6GKYejC1KTOoCywJjuocWhEmcU1HKfbTAksq8EoweoeMY1wkQmFaH6IjiKmGCLdDbEgYLIbOubSHAYCBmbsjefe_NNo7gBsiMT-VhDHp0fohXmc42fjN132ne6Ag2M8HHmEcwc013WRwnuz1FB63uIpz9xBP0-nD_cveYr56XT3e3q9xUZT3mnBuLZQkNyJITQRi2gDnTTUnLikMjLTY1l7QVNeOS1ClaI0ijRSNFC5KeoMvd3E3wHxPEUfUuGug6PYCfoioJ5YwxTllCqx36fXCAVm2C63XYKoLVrFWt1U6rmrUqLFWyltoufjZMTQ_2r-nXYwJudgCkPz8dBBWNm21aF5IUZb37f8MXL7qMEw</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Cohen, E.</creator><creator>Margalit, I.</creator><creator>Shochat, T.</creator><creator>Goldberg, E.</creator><creator>Krause, I.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>Gender differences in homocysteine concentrations, a population-based cross-sectional study</title><author>Cohen, E. ; Margalit, I. ; Shochat, T. ; Goldberg, E. ; Krause, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-66cd092ebe92617150de065ab23246eb9d0c8693f7856918f78dc71ba7b97fe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - epidemiology</topic><topic>Biomarkers - blood</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Folate</topic><topic>Folic Acid Deficiency - blood</topic><topic>Folic Acid Deficiency - epidemiology</topic><topic>Gender</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - blood</topic><topic>Hyperhomocysteinemia - diagnosis</topic><topic>Hyperhomocysteinemia - epidemiology</topic><topic>Israel</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Vitamin B 12 Deficiency - blood</topic><topic>Vitamin B 12 Deficiency - epidemiology</topic><topic>Vitamin B12</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, E.</creatorcontrib><creatorcontrib>Margalit, I.</creatorcontrib><creatorcontrib>Shochat, T.</creatorcontrib><creatorcontrib>Goldberg, E.</creatorcontrib><creatorcontrib>Krause, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, E.</au><au>Margalit, I.</au><au>Shochat, T.</au><au>Goldberg, E.</au><au>Krause, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender differences in homocysteine concentrations, a population-based cross-sectional study</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2019-01</date><risdate>2019</risdate><volume>29</volume><issue>1</issue><spage>9</spage><epage>14</epage><pages>9-14</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>High concentrations of homocysteine are considered a risk factor for atherosclerosis and coronary artery disease. The aim of this study was to assess whether or not there are gender differences in the plasma concentrations of homocysteine.
Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000–2014. Cross sectional analysis was carried out on 9237 men and 4353 women. Mean (SD) age of the study sample was 48.4 (9.7) and 47.7 (9.7) years for men and women respectively. Average homocysteine concentrations were 12.6 (5.9) and 9.6 (3.2) μmol/L in men and women respectively (p < 0.001). Prevalence of homocysteine concentrations above 15 μmol/L was found to be significantly higher in men than in women; 15.5% vs 3.9% respectively (p < 0.001). Low concentrations of vitamin (B12 < 200 pmol/L) and low concentrations of folate (<12 nmol/L) were found to be significantly higher in men than in women 20.4% vs. 16.0% and 18.5% vs. 10.8% respectively. Compared to women, men had a significantly higher odds ratio (95% CI) of having homocysteine concentrations above 15 μmol/L: non adjusted model, 4.47 (3.80–5.26); adjusted model for age, smoking status, body mass index, diabetes mellitus, kidney function and low serum concentrations of vitamin B12 and folate, 3.44 (2.89–4.09).
Plasma homocysteine concentrations are higher in men than in women. This may be a contributing factor to gender differences for developing atherosclerosis and coronary artery disease.
•High levels of homocysteine are considered a risk factor for atherosclerosis.•Data on gender differences and homocysteine levels are scarce.•The current study assessed homocysteine gender differences in 13,590 subjects.•Both plasma homocysteine concentrations and prevalence of hyperhomocysteinemia were higher in men.•Hyperhomocysteinemia is another gender difference in the risk of atherosclerosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30459075</pmid><doi>10.1016/j.numecd.2018.09.003</doi><tpages>6</tpages></addata></record> |
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| source | ScienceDirect Freedom Collection |
| subjects | Adult Aged Aged, 80 and over Atherosclerosis - blood Atherosclerosis - epidemiology Biomarkers - blood Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - epidemiology Cross-Sectional Studies Female Folate Folic Acid Deficiency - blood Folic Acid Deficiency - epidemiology Gender Homocysteine Homocysteine - blood Humans Hyperhomocysteinemia - blood Hyperhomocysteinemia - diagnosis Hyperhomocysteinemia - epidemiology Israel Male Middle Aged Prevalence Prognosis Risk Factors Sex Factors Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - epidemiology Vitamin B12 Young Adult |
| title | Gender differences in homocysteine concentrations, a population-based cross-sectional study |
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