Intranasal curcumin regulates chronic asthma in mice by modulating NF-ĸB activation and MAPK signaling

Curcumin, a natural product found in the plant Curcuma longa, has been reported to have diverse range of molecular targets that influence numerous biochemical and molecular cascades including anti-inflammatory and antioxidant properties. The aim of the study was to investigate the therapeutic potent...

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Bibliographic Details
Published in:	Phytomedicine (Stuttgart) 2018-12, Vol.51, p.29-38
Main Authors:	Chauhan, Preeti S., Singh, D.K., Dash, D., Singh, Rashmi
Format:	Article
Language:	English
Subjects:	Administration, Intranasal aerosols Animals antioxidants asthma Asthma - drug therapy blood serum Curcuma - chemistry Curcuma longa Curcumin Curcumin - pharmacology Cyclooxygenase 2 - metabolism Lung - drug effects lungs MAPK Mice Mice, Inbred BALB C mitogen-activated protein kinase Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism nitrites Nuclear factor κB and reactive oxygen species Ovalbumin Phosphorylation signal transduction Signal Transduction - drug effects therapeutics transcription factor NF-kappa B
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