Caryopincaolide M, a rearranged abietane diterpenoid with new skeleton and a new iridoid from Caryopteris incana

Caryopincaolide M ( 1 ), a new rearranged abietane diterpenoid with an unusual pent-4-enoic acid group on a 6/6/5 tricyclic ring system, and 7- epi -8-dehydroxypatriscabrol ( 3 ), a new iridoid, together with 17 known compounds, have been isolated from the whole plant of Caryopteris incana (Thunb.)...

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Bibliographic Details
Published in:Journal of natural medicines 2019-01, Vol.73 (1), p.210-216
Main Authors: Zhang, Cheng-Gang, Chen, Ting, Mao, Xu-Dong, Zhao, Sen-Miao, Chou, Gui-Xin
Format: Article
Language:English
Subjects:
Abietanes - chemistry
Biomedical and Life Sciences
Biomedicine
Caryopteris incana
Complementary & Alternative Medicine
Enzymes
Flowers & plants
Herbs
Medicinal Chemistry
Molecular Structure
Organic chemicals
Original Paper
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Extracts - chemistry
Plant Sciences
α-Glucosidase
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Summary:Caryopincaolide M ( 1 ), a new rearranged abietane diterpenoid with an unusual pent-4-enoic acid group on a 6/6/5 tricyclic ring system, and 7- epi -8-dehydroxypatriscabrol ( 3 ), a new iridoid, together with 17 known compounds, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1-D and 2-D NMR, IR, and mass spectroscopic data. Compounds 1–5 were evaluated for their inhibitory activities against enzyme α -glucosidase, and the results showed that only 1 has moderate inhibitory activity against enzyme α -glucosidase with IC 50 at 528.3 ± 12.37 mg/L.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-018-1268-9