A comparison of long-term outcomes of nanohydroxyapatite/polyamide-66 cage and titanium mesh cage in anterior cervical corpectomy and fusion: A clinical follow-up study of least 8 years

• Published in: Clinical neurology and neurosurgery 2019-01, Vol.176, p.25-29
• Main Authors: Hu, Bowen, Wang, Linnan, Song, Yueming, Hu, Yujie, Lyu, Qiunan, Liu, Limin, Zhu, Ce, Zhou, Chunguang, Yang, Xi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cages; Cervical spine; Cervical Vertebrae - surgery; Clinical outcomes; Corpectomy; Female; Follow-Up Studies; Fusion; Humans; Lordosis - surgery; Male; Middle Aged; Nano-hydroxyapatite/polyamide66 cage; Neurology; Nylons - adverse effects; Polyamide resins; Prostheses and Implants; Reconstructive Surgical Procedures - methods; Spinal Cord Diseases - surgery; Spinal Fusion - instrumentation; Spondylosis - surgery; Surgeons; Surgery; Surgical Mesh - adverse effects; Titanium; Titanium - adverse effects; Titanium mesh cage; Treatment Outcome; Vertebrae
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2018.11.015

The long-term follow-up study showed that the n-HA/PA66 cage is associated with less subsidence and better clinical results than the TMC at 8 years after single-level ACCF, which may be a more promising choice than the TMC in ACCF. [Display omitted] •The nanohydroxyapatite/polyamide-66 cage showed lower subsidence and better clinical outcome rather than titanium mesh cage at 8 years after single-level anterior cervical corpectomy and fusion.•No significant difference of final segmental lordosis and cervical lordosis were found between nanohydroxyapatite/polyamide-66 group and titanium mesh cage group.•The nanohydroxyapatite/polyamide-66 cage could be superior to the titanium mesh cage in anterior cervical construction. The nanohydroxyapatite/polyamide-66 (n-HA/PA66) cage is a novel biomimetic nonmetal cage device that is now used in some medical centers, while the titanium mesh cage (TMC) is a typical metal cage device that has been widely used for decades. This study was performed to compare the long-term outcomes of these two different cages in patients undergoing anterior cervical corpectomy. This retrospective study involved 107 patients who underwent single-level anterior corpectomy using either a TMC (n = 52) or an n-HA/PA66 cage (n = 55) for treatment of cervical degenerative disease with a minimum follow-up of 8 years. Their radiographic data (cage subsidence, fusion status, segmental sagittal alignment, and cervical spine degeneration) and clinical data [visual analog scale (VAS) and Japanese Orthopedic Association (JOA) scores] were evaluated preoperatively, postoperatively, and at the final follow-up. The mean duration of follow-up was 103.6 ± 6.3 months in the n-HA/PA66 group and 102.4 ± 4.6 months in the TMC group. The n-HA/PA66 group and the TMC group had similar final fusion rates (97% vs. 94%, respectively). The final n-HA/PA66 cage subsidence was 2.4 ± 1.0 mm with 18.2% subsidence of >3 mm, which was significantly lower than the respective 3.0 ± 0.7 mm and 40.4% for the TMC (p