Reye syndrome and sudden death symptoms after oral administration of nimesulide due to upper respiratory tract infection in a boy

• Published in: Zhongguo dang dai er ke za zhi 2018-11, Vol.20 (11), p.944-949
• Main Authors: Feng, Li-Fang, Chen, Xiao-Hong, Li, Dong-Xiao, Li, Xi-Yuan, Song, Jin-Qing, Jin, Ying, Yang, Yan-Ling
• Format: Article
• Language: Chinese
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2018.11.013

A boy aged 6 years and 3 months developed upper respiratory tract infection and pyrexia 2 months ago and was given oral administration of nimesulide by his parents according to directions. Half an hour later, the boy experienced convulsions and cardiopulmonary arrest, and emergency examination found hypoketotic hypoglycemia, metabolic acidosis, significant increases in serum aminotransferases and creatine kinase, and renal damage. Recovery of consciousness and vital signs was achieved after cardiopulmonary resuscitation, but severe mental and movement regression was observed. The boy had a significant reduction in free carnitine in blood and significant increases in medium- and long-chain fatty acyl carnitine, urinary glutaric acid, 3-hydroxy glutaric acid, isovalerylglycine, and ethylmalonic acid, suggesting the possibility of multiple acyl-CoA dehydrogenase deficiency. After the treatment with vitamin B2, L-carnitine, and bezafibrate, the boy gradually improved, and reexamination after 3 months showed norma