Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59

This is the 59th report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). A workshop on Skin Sensitisation and Epidermal Disposition was held at ECVAM (Ispra, Italy) on 30-31 January 2006, under the chairmanship of David Basketter. The curre...

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Published in:Alternatives to laboratory animals 2007-03, Vol.35 (1), p.137-154
Main Authors: Basketter, David, Pease, Camilla, Kasting, Gerald, Kimber, Ian, Casati, Silvia, Cronin, Mark, Diembeck, Walter, Gerberick, Frank, Hadgraft, Jonathan, Hartung, Thomas, Marty, Jean-Paul, Nikolaidis, Efstathios, Patlewicz, Grace, Roberts, David, Roggen, Erwin, Rovida, Costanza, van de Sandt, Johannes
Format: Article
Language:English
Subjects:
Allergens - immunology
Allergens - pharmacokinetics
Allergens - toxicity
Animal Testing Alternatives
Animals
Cells, Cultured
Guidelines as Topic
Humans
Risk Assessment
Skin - drug effects
Skin - immunology
Skin - metabolism
Skin Absorption
Skin Tests - methods
Toxicity Tests - methods
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Summary:This is the 59th report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). A workshop on Skin Sensitisation and Epidermal Disposition was held at ECVAM (Ispra, Italy) on 30-31 January 2006, under the chairmanship of David Basketter. The current status of approaches used to measure the disposition of chemicals in skin compartments was reviewed, with particular emphasis on proposing recommendations on how best to use such information to reduce, refine and/or eliminate the need for animal testing, according to the Three Rs principle. The key focus was the relevance of information on epidermal disposition, and how best to integrate such information into non-animal testing strategies for skin sensitisation.
ISSN:0261-1929
2632-3559
DOI:10.1177/026119290703500124