Modulatory role of vanadium on trace element profile in diethylnitrosamine-induced rat hepatocarcinogenesis

Particle-induced X-ray emission (PIXE) analysis was employed in the present study to investigate the chemopreventive potential of vanadium in influencing trace elemental profile and antioxidant status in chemical carcinogenesis. The elements with Z=15–40 were studied. Data reveal remarkable alterati...

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Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 2000-09, Vol.170 (1), p.156-162
Main Authors: Chakraborty, A, Selvaraj, S, Sudarshan, M, Dutta, R.K, Ghugre, S.S, Chintalapudi, S.N
Format: Article
Language:English
Subjects:
Antioxidants
Aromatic compounds
Biology
Carcinogens
Composition
Particle beams
Protons
Tissue
Trace elements
X ray analysis
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Summary:Particle-induced X-ray emission (PIXE) analysis was employed in the present study to investigate the chemopreventive potential of vanadium in influencing trace elemental profile and antioxidant status in chemical carcinogenesis. The elements with Z=15–40 were studied. Data reveal remarkable alterations in elemental composition in the hepatic tissue of diethylnitrosamine (DENA)-induced Sprague–Dawley male rats (intraperitoneal (ip) dose: 200 mg/kg body weight) after four weeks of induction. Several elements like Mn, Cu, Zn, Rb showed large depletion while other elements like Fe, Ca, K, Br showed large enhancement in comparison to that of the normal control animals. These elements compete for binding sites in the cell, change its enzymatic activity and exert direct or indirect action on the carcinogenic process. Supplementary vanadium (0.5 ppm ad libitum in drinking water) has shown effective modulation by alteration in the concentration of trace elements in the tumorigenic tissue ( P
ISSN:0168-583X
1872-9584
DOI:10.1016/S0168-583X(00)00088-4