Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB sub(2) agonists for the treatment of inflammatory pain

A series of 3-amino-6-aryl-pyridazines have been identified as CB sub(2) agonists with high efficacy and selectivity against the CB sub(1) receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which led to the identification of pyridazine analogue 35, a comp...

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Published in:Bioorganic & medicinal chemistry letters 2010-01, Vol.20 (2), p.465-468
Main Authors: Gleave, Robert J, Beswick, Paul J, Brown, Andrew J, Giblin, Gerard MP, Goldsmith, Paul, Haslam, Carl P, Mitchell, William L, Nicholson, Neville H, Page, Lee W, Patel, Sadhana, Roomans, Susan, Slingsby, Brian P, Swarbrick, Martin E
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container_issue 2
container_start_page 465
container_title Bioorganic & medicinal chemistry letters
container_volume 20
creator Gleave, Robert J
Beswick, Paul J
Brown, Andrew J
Giblin, Gerard MP
Goldsmith, Paul
Haslam, Carl P
Mitchell, William L
Nicholson, Neville H
Page, Lee W
Patel, Sadhana
Roomans, Susan
Slingsby, Brian P
Swarbrick, Martin E
description A series of 3-amino-6-aryl-pyridazines have been identified as CB sub(2) agonists with high efficacy and selectivity against the CB sub(1) receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which led to the identification of pyridazine analogue 35, a compound with high potency in an in vivo model of inflammatory pain.
doi_str_mv 10.1016/j.bmcl.2009.11.117
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title Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB sub(2) agonists for the treatment of inflammatory pain
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