Young spontaneously hypertensive rats (SHRs) display prodromal schizophrenia-like behavioral abnormalities

• Published in: Progress in neuro-psychopharmacology & biological psychiatry 2019-03, Vol.90, p.169-176
• Main Authors: Niigaki, Suzy Tamie, Peres, Fernanda Fiel, Ferreira, Lizia, Libanio, Tania, Gouvea, Douglas Albuquerque, Levin, Raquel, Almeida, Valeria, Silva, Neide Derci, Diana, Mariana Cepollaro, Suiama, Mayra Akimi, Calzavara, Mariana Bendlin, Abilio, Vanessa Costhek
• Format: Article
• Language: English
• Subjects: Animal model; Prodromal phase; Schizophrenia
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2018.11.020

The Spontaneously Hypertensive Rat (SHR) strain has been suggested as an animal model of schizophrenia, considering that adult SHRs display behavioral abnormalities that mimic the cognitive, psychotic and negative symptoms of the disease and are characteristic of its animal models. SHRs display: (I) deficits in fear conditioning and latent inhibition (modeling cognitive impairments), (II) deficit in prepulse inhibition of startle reflex (reflecting a deficit in sensorimotor gating, and associated with psychotic symptoms), (III) diminished social behavior (modeling negative symptoms) and (IV) hyperlocomotion (modeling the hyperactivity of the dopaminergic mesolimbic system/ psychotic symptoms). These behavioral abnormalities are reversed specifically by the administration of antipsychotic drugs. Here, we performed a behavioral characterization of young (27–50 days old) SHRs in order to investigate potential early behavioral abnormalities resembling the prodromal phase of schizophrenia. When compared to Wistar rats, young SHRs did not display hyperlocomotion or PPI deficit, but exhibited diminished social interaction and impaired fear conditioning and latent inhibition. These findings are in accordance with the clinical course of schizophrenia: manifestation of social and cognitive impairments and absence of full-blown psychotic symptoms in the prodromal phase. The present data reinforce the SHR strain as a model of schizophrenia, expanding its validity to the prodromal phase of the disorder. •Young SHRs display behaviors that mimic the negative and cognitive symptoms.•Young SHRs do not display behaviors that mimic the positive symptoms.•The behavioral profile of young SHRs is in line with schizophrenia's prodromal phase.