Body-Weight Fluctuation and Incident Diabetes Mellitus, Cardiovascular Disease, and Mortality: A 16-Year Prospective Cohort Study

Body-weight fluctuation (weight cycling) has been found to be associated with higher mortality and cardiovascular events in patients with coronary artery disease. However, there are very limited data regarding the relationship between body-weight fluctuation and health-related outcomes in the genera...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2019-03, Vol.104 (3), p.639-646
Main Authors: Oh, Tae Jung, Moon, Jae Hoon, Choi, Sung Hee, Lim, Soo, Park, Kyong Soo, Cho, Nam H, Jang, Hak Chul
Format: Article
Language:English
Subjects:
Analysis
Blood pressure
Body Mass Index
Body Weight
Cardiac patients
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cohort analysis
Coronary artery
Coronary heart disease
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Diabetes Mellitus - etiology
Epidemiology
Female
Follow-Up Studies
Genomes
Glycosylated hemoglobin
Health aspects
Health risk assessment
Heart diseases
Humans
Male
Middle Aged
Mortality
Obesity
Obesity - complications
Obesity - mortality
Prospective Studies
Republic of Korea - epidemiology
South Korea
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Summary:Body-weight fluctuation (weight cycling) has been found to be associated with higher mortality and cardiovascular events in patients with coronary artery disease. However, there are very limited data regarding the relationship between body-weight fluctuation and health-related outcomes in the general population. We examined whether body-weight fluctuation can associate incident diabetes mellitus and cardiovascular events, and mortality in a Korean population from the Korean Genome and Epidemiology Study. The intraindividual fluctuations of body weight were calculated by average successive variability (ASV); health-related outcomes were collected every 2 years for 16 years in 3,678 participants. Participants with a high ASV of body weight were more obese and had higher blood pressure and HbA1c levels at baseline than those with a low ASV of body weight. A 1-unit increase in ASV of body weight was associated with increase in mortality (HR, 1.46; 95% CI, 1.32 to 1.62; P < 0.001). However, the association between the ASV of body weight and incident diabetes mellitus seemed to be influenced by baseline body mass index (BMI): negative effect in subjects with BMI
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2018-01239