Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder

•We tested exercise-induced BDNF level changes in 30 patients with depression (MDD).•For the first time, we apply a more precise analysis method of BDNF changes in MDD.•Change mechanisms can be disentangled by taking peripheral factors into account.•Results remain significant when adjusted for plasm...

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Published in:Psychoneuroendocrinology 2019-04, Vol.102, p.212-215
Main Authors: Kallies, Gunnar, Rapp, Michael A., Fydrich, Thomas, Fehm, Lydia, Tschorn, Mira, Terán, Christina, Schwefel, Melanie, Pietrek, Anou, Henze, Romy, Hellweg, Rainer, Ströhle, Andreas, Heinzel, Stephan, Heissel, Andreas
Format: Article
Language:English
Subjects:
Adult
Brain-derived neurotrophic factor (BDNF)
Brain-Derived Neurotrophic Factor - analysis
Brain-Derived Neurotrophic Factor - blood
Depressive Disorder, Major - blood
Depressive Disorder, Major - metabolism
Exercise - physiology
Exercise Therapy - methods
Female
Humans
Major depressive disorder
Male
Middle Aged
Physical exercise
Platelets
Rest - physiology
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Summary:•We tested exercise-induced BDNF level changes in 30 patients with depression (MDD).•For the first time, we apply a more precise analysis method of BDNF changes in MDD.•Change mechanisms can be disentangled by taking peripheral factors into account.•Results remain significant when adjusted for plasma volume shift and platelet count.•BDNF increase may be due to interplay of peripheral and possibly brain-derived factors. Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p 
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2018.12.015