Impact of the homogeneous and heterogeneous risk factors on the incidence and survival outcome of bone metastasis in NSCLC patients

Purpose Bone metastases (BM) is reported as the most frequent distant metastasis in non-small cell lung cancer (NSCLC), but the risk factors for the incidence and prognosis of BM patients in NSCLC have not been extensively elucidated. This study aimed to find risk factors to predict BM patients’ mor...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2019-03, Vol.145 (3), p.737-746
Main Authors: Song, Qian, Shang, Jun, Zhang, Chufan, Zhang, Lanlin, Wu, Xianghua
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer Research
Health risk assessment
Hematology
Internal Medicine
Liver
Lung cancer
Lymph nodes
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Morbidity
Non-small cell lung carcinoma
Oncology
Original Article – Clinical Oncology
Risk factors
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Summary:Purpose Bone metastases (BM) is reported as the most frequent distant metastasis in non-small cell lung cancer (NSCLC), but the risk factors for the incidence and prognosis of BM patients in NSCLC have not been extensively elucidated. This study aimed to find risk factors to predict BM patients’ morbidity and survival outcome in NSCLC. Methods 63,505 patients of NSCLC in the Surveillance, Epidemiology and End Results database diagnosed from 2010 to 2015 were used to analyze risk factors for developing BM by conducting multivariable logistic regression. Of these patients, 6152 and 5664 BM patients diagnosed between 2010 and 2014 were selected to investigate predictive factors for BM overall survival (OS) and cancer-specific survival (CSS) using the multivariable Cox proportional hazards regression. Results There were overall 7486 (11.79%) BM patients in NSCLC. The homogeneous risk factors for BM patients’ morbidity and survival outcome included male, higher T stage, lymph node involvement, poor differentiation grade, brain metastases, and liver metastases. Married status, adenocarcinoma type and lung metastases were positively correlated with BM incidence, while older age, white race, unmarried status, and SCC and other NSCLC types could predict poor OS and CSS of BM in NSCLC. Conclusions The homogeneous and heterogeneous risk factors for morbidity and survival outcome of BM patients could help physicians in more precise and individualized screening and therapies for BM patients in NSCLC.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-018-02826-7