Untargeted metabolite profiling and phytochemical analysis of Micromeria fruticosa L. (Lamiaceae) leaves

[Display omitted] •Metabolites from Palestinian Micromeria fruticosa was reported for the first time.•Over 200 components were detected and tentatively identified by UHPLC-DAD-MS2 method.•M. fruticosa showed to be a natural source of phytochemical and functional ingredients.•Sulfate derivatives are...

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Bibliographic Details
Published in:Food chemistry 2019-05, Vol.279, p.128-143
Main Authors: Abu-Reidah, Ibrahim M., Arráez-Román, David, Al-Nuri, Mohammed, Warad, Ismail, Segura-Carretero, Antonio
Format: Article
Language:English
Subjects:
Chromatography, High Pressure Liquid
Flavonoids
Lamiaceae
Lamiaceae - chemistry
Lamiaceae - metabolism
Micromeria fruticosa
Phenolics
Phenols - analysis
Phenols - chemistry
Phytochemicals - analysis
Phytochemicals - chemistry
Plant Extracts - chemistry
Plant Leaves - chemistry
Plant Leaves - metabolism
Secondary metabolites
Spectrometry, Mass, Electrospray Ionization - methods
Sulfate derivatives
Ultra-high-performance liquid chromatography-diode array detection-electrospray ionization-quadrupole time of flight-mass spectrometry (UHPLC-DAD-ESI-QTOF-MS2)
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Summary:[Display omitted] •Metabolites from Palestinian Micromeria fruticosa was reported for the first time.•Over 200 components were detected and tentatively identified by UHPLC-DAD-MS2 method.•M. fruticosa showed to be a natural source of phytochemical and functional ingredients.•Sulfate derivatives are unusual components newly identified in the Micromeria genus. Micromeria fruticosa is an important crop, is widely used in the Mediterranean basin as food and in folk medicine, owing to its health-promoting properties, partially due to the secondary metabolite composition. However, complete information on the phyto-metabolites in M. fruticosa is still lacking. Plant leaves were extracted in methanol (80%), then the phyto-metabolites were separated on C18 column and an extensive characterization using UHPLC–DAD-ESI–QTOF–MS2 method in two ionization modes was established. A total of 215 phenolics and other compounds were tentatively identified, offering the first comprehensive study available on the phytochemicals from M. fruticosa. Over 180 phytochemicals (87 flavonoids, 41 phenolic acids, 16 terpenoids, 8 sulfate derivatives, 7 iridoids, and others) are reported in Micromeria for the first time. M. fruticosa can be a promising source of functional ingredients and has use in the food, pharma and nutraceutical industries.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2018.11.144