Quantitation and distribution of metallic elements in sequestra of medication-related osteonecrosis of jaw (MRONJ) using inductively coupled plasma atomic emission spectroscopy and synchrotron radiation X-ray fluorescence analysis

Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive agents like bisphosphonates. Abnormal concentrations of various trace metallic elements contained in bone minerals have been associated with MRONJ. In this study, we focused on trace metallic elements c...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2019-07, Vol.37 (4), p.676-684
Main Authors: Komiya, Ruri, Wada, Takahiro, Tsushima, Fumihiko, Sakamoto, Kei, Ikeda, Tohru, Yamaguchi, Akira, Harada, Hiroyuki, Uo, Motohiro
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bisphosphonate-Associated Osteonecrosis of the Jaw - metabolism
Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology
Bisphosphonates
Chromium
Copper
Decalcification
Female
Fluorescence
Humans
Inflammation
Jaw
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Article
Orthopedics
Osteomyelitis
Osteonecrosis
Plasma
Quantitation
Spectrophotometry, Atomic - methods
Spectroscopy
Spectrum analysis
Synchrotrons
Trace Elements - analysis
X-Rays
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Summary:Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive agents like bisphosphonates. Abnormal concentrations of various trace metallic elements contained in bone minerals have been associated with MRONJ. In this study, we focused on trace metallic elements contained in the MRONJ sequestrum; their content and distribution were compared to those in osteomyelitis and non-inflammatory bones using inductively coupled plasma atomic emission spectroscopy (ICP-AES) and synchrotron radiation X-ray fluorescence analysis (SR-XRF). On ICP-AES analyses, various trace elements (Co, Cr, Cu, Fe, K, Mg, Ni, Sb, Ti, V, Pb) were significantly more in MRONJ sequestra than non-inflammatory bones. The Cu content was significantly higher in MRONJ sequestra than osteomyelitis and non-inflammatory bones. The Cu content in MRONJ sequestra was high even after decalcification. Additionally, Cu was distributed along the trabecular structures in decalcified MRONJ specimens, as observed using SR-XRF analysis. Therefore, this study was indicative of the characteristic behavior of Cu in MRONJ.
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-018-0975-3