Hyperuricemia is associated with acute kidney injury and all‐cause mortality in hospitalized patients

ABSTRACT Aim Hyperuricemia is a risk factor for high morbidity and mortality in several diseases. However, the relationship between uric acid (UA) and the risk of acute kidney injury (AKI) and mortality remain unresolved in hospitalized patients. Methods Data from 18 444 hospitalized patients were r...

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Published in:Nephrology (Carlton, Vic.) Vic.), 2019-07, Vol.24 (7), p.718-724
Main Authors: Kang, Min Woo, Chin, Ho Jun, Joo, Kwon‐Wook, Na, Ki Young, Kim, Sejoong, Han, Seung Seok
Format: Article
Language:English
Subjects:
acute kidney injury
Acute Kidney Injury - etiology
Acute Kidney Injury - mortality
Adult
Aged
Female
Females
Hospital Mortality
Humans
Hyperuricemia
Hyperuricemia - complications
Kidneys
Male
Males
Middle Aged
Morbidity
Mortality
Retrospective Studies
Risk factors
survival
Uric acid
Uric Acid - blood
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Summary:ABSTRACT Aim Hyperuricemia is a risk factor for high morbidity and mortality in several diseases. However, the relationship between uric acid (UA) and the risk of acute kidney injury (AKI) and mortality remain unresolved in hospitalized patients. Methods Data from 18 444 hospitalized patients were retrospectively reviewed. The odds ratio (OR) for AKI and the hazard ratio (HR) for all‐cause mortality were calculated based on the UA quartiles after adjustment for multiple variables. All analyses were performed after stratification by sex. Results The fourth quartile group (male, UA > 6.7 mg/dL; female, UA > 5.4 mg/dL) showed a higher risk of AKI compared with the first quartile group (male, UA 
ISSN:1320-5358
1440-1797
DOI:10.1111/nep.13559