Innate and Innate-Like Immune System in Hypertension and Vascular Injury

Purpose of Review To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury. Recent Findings Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lym...

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Bibliographic Details
Published in:Current hypertension reports 2019-01, Vol.21 (1), p.4-9, Article 4
Main Authors: Higaki, Akinori, Caillon, Antoine, Paradis, Pierre, Schiffrin, Ernesto L.
Format: Article
Language:English
Subjects:
Animals
Antigen presentation
Blood pressure
Cardiology
Cytokines
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Family Medicine
General Practice
Humans
Hypertension
Hypertension - immunology
Immune system
Immunity, Innate - physiology
Inflammation
Inflammation - immunology
Inflammation - metabolism
Inflammation and Cardiovascular Diseases (A. Kirabo
Internal Medicine
Lymphocytes
Lymphocytes - immunology
Lymphocytes - metabolism
Macrophages - immunology
Macrophages - metabolism
Medicine
Medicine & Public Health
Metabolic Diseases
Myeloid-Derived Suppressor Cells - immunology
Myeloid-Derived Suppressor Cells - metabolism
Nephrology
Neutrophils
Neutrophils - immunology
Neutrophils - metabolism
Pathogens
Primary Care Medicine
Section Editor
T cell receptors
Topical Collection on Inflammation and Cardiovascular Diseases
Tumor necrosis factor-TNF
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Summary:Purpose of Review To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury. Recent Findings Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like γδ T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and γδ T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity. Summary Innate and innate-like immunity play a leading role in the pathophysiology of hypertension. Recent advances in this field provide us clues for future therapeutic approaches.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-019-0907-1