Effect of 3 lactobacilli on immunoregulation and intestinal microbiota in a β-lactoglobulin–induced allergic mouse model

Milk is one of the earliest and most common allergen sources in the world, with β-lactoglobulin representing a major allergen protein. Numerous studies have reported that probiotics exert antiallergic and anti-inflammatory effects. Here, we examined the effects of 3 strains of Lactobacillus on immun...

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Bibliographic Details
Published in:Journal of dairy science 2019-03, Vol.102 (3), p.1943-1958
Main Authors: Fu, Guiming, Zhao, Kui, Chen, Hui, Wang, Yuanyuan, Nie, Lijuan, Wei, Hua, Wan, Cuixiang
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Female
food allergy
Food Hypersensitivity - immunology
Gastrointestinal Microbiome - immunology
Immunomodulation - physiology
immunoregulation
intestinal microbiota
Lactobacillus
Lactobacillus - immunology
Lactobacillus plantarum - physiology
Lactoglobulins - immunology
Mice
Mice, Inbred BALB C
Probiotics - administration & dosage
Th1-Th2 Balance - physiology
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Summary:Milk is one of the earliest and most common allergen sources in the world, with β-lactoglobulin representing a major allergen protein. Numerous studies have reported that probiotics exert antiallergic and anti-inflammatory effects. Here, we examined the effects of 3 strains of Lactobacillus on immunomodulatory functions, intestinal barrier functions, and intestinal microbiota through a β-lactoglobulin–induced allergic mouse model. We found that the oral administration of Lactobacillus plantarum ZDY2013 and Lactobacillus rhamnosus GG suppressed allergic response, attenuating serum IgE and relieving anaphylaxis symptoms. The 3 strains of Lactobacillus could induce T helper (Th) 1 or T regulatory cells to differentiate to inhibit the Th2-biased response for regulating Th1/Th2 immune balance. Furthermore, L. plantarum ZDY2013 and L. rhamnosus GG enhanced intestinal barrier function through the regulation of tight junction. We also found that L. plantarum ZDY2013 and L. plantarum WLPL04 could regulate alterations in intestinal microbiota caused by allergies. In particular, Rikenella, Ruminiclostridium, and Lachnospiraceae UCG-006 were considerably reduced after treatment with L. plantarum ZDY2013 and L. plantarum WLPL04. These results suggested that 3 Lactobacillus strains may serve as an effective tool for the treatment of food allergies by regulating immune and gut microbiota.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.2018-15683