Vitamin D supplementation increases adipokine concentrations in overweight or obese adults

Purpose Vitamin D regulates adipokine production in vitro; however, clinical trials have been inconclusive. We conducted secondary analyses of a randomized controlled trial to examine whether vitamin D supplementation improves adipokine concentrations in overweight/obese and vitamin D-deficient adul...

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Bibliographic Details
Published in:European journal of nutrition 2020-02, Vol.59 (1), p.195-204
Main Authors: Mousa, Aya, Naderpoor, Negar, Wilson, Kirsty, Plebanski, Magdalena, de Courten, Maximilian P. J., Scragg, Robert, de Courten, Barbora
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Absorptiometry
Adiponectin
Body fat
Body weight
Chemistry
Chemistry and Materials Science
Clinical trials
Dietary supplements
Dual energy X-ray absorptiometry
Flow cytometry
Hip
Leptin
NCT
NCT02112721
Nutrition
Obesity
Original Contribution
Overweight
Physical activity
Vitamin D
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Summary:Purpose Vitamin D regulates adipokine production in vitro; however, clinical trials have been inconclusive. We conducted secondary analyses of a randomized controlled trial to examine whether vitamin D supplementation improves adipokine concentrations in overweight/obese and vitamin D-deficient adults. Methods Sixty-five individuals with a BMI ≥ 25 kg/m 2 and 25-hydroxyvitamin D (25(OH)D) ≤ 50 nmol/L were randomized to oral cholecalciferol (100,000 IU single bolus followed by 4,000 IU daily) or matching placebo for 16 weeks. We measured BMI, waist-to-hip ratio, % body fat (dual X-ray absorptiometry), serum 25(OH)D (chemiluminescent immunoassay) and total adiponectin, leptin, resistin, and adipsin concentrations (multiplex assay; flow cytometry). Sun exposure, physical activity, and diet were assessed using questionnaires. Results Fifty-four participants completed the study (35M/19F; mean age = 31.9 ± 8.5 years; BMI = 30.9 ± 4.4 kg/m 2 ). After 16 weeks, vitamin D supplementation increased 25(OH)D concentrations compared with placebo (57.0 ± 21.3 versus 1.9 ± 15.1 nmol/L, p   0.05). After adjustment for baseline values, season, sun exposure, and dietary vitamin D intake, there was a greater increase in adiponectin ( β [95%CI] = 13.7[2.0, 25.5], p  = 0.02) and leptin ( β [95%CI] = 22.3[3.8, 40.9], p  = 0.02) in the vitamin D group compared with placebo. Results remained significant after additional adjustment for age, sex, and % body fat ( p  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-019-01899-5