125 I interstitial brachytherapy in management of pediatric skull base tumors

The purpose of this study was to present our preliminary assessment of the safety and efficacy of I interstitial brachytherapy (IBT) in the management of pediatric skull base tumors. Thirty pediatric patients with skull base tumors treated with I IBT from April 2007 to May 2017 were included in this...

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Bibliographic Details
Published in:Pediatric blood & cancer 2019-05, Vol.66 (5), p.e27622-e27622
Main Authors: Chen, Peng, Wu, Wen-Jie, Yi, Zhi-Qiang, Ma, Xiao-Li, Zhao, Wei-Hong, Zhang, Jian-Guo
Format: Article
Language:English
Subjects:
Adolescent
Brachytherapy - mortality
Child
Child, Preschool
Feasibility Studies
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Iodine Radioisotopes - therapeutic use
Male
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - radiotherapy
Skull Base Neoplasms - pathology
Skull Base Neoplasms - radiotherapy
Survival Rate
Treatment Outcome
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Summary:The purpose of this study was to present our preliminary assessment of the safety and efficacy of I interstitial brachytherapy (IBT) in the management of pediatric skull base tumors. Thirty pediatric patients with skull base tumors treated with I IBT from April 2007 to May 2017 were included in this study. The probabilities of local control (LC) and overall survival (OS) were calculated by the Kaplan-Meier method. The one- and two-year LC rates were 96.7% and 74.8%, respectively. The one- and two-year OS rates were 93.3% and 72.2%, respectively. No severe acute toxicity was observed. Severe late toxicities were observed in one (3.33%) of 30 patients. I IBT is effective and safe in the management of pediatric skull base tumors, with satisfactory cosmetic and functional outcomes.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.27622