Commissioning of a fluoroscopic‐based real‐time markerless tumor tracking system in a superconducting rotating gantry for carbon‐ion pencil beam scanning treatment

• Published in: Medical physics (Lancaster) 2019-04, Vol.46 (4), p.1561-1574
• Main Authors: Mori, Shinichiro, Sakata, Yukinobu, Hirai, Ryusuke, Furuichi, Wataru, Shimabukuro, Kazuki, Kohno, Ryosuke, Koom, Woong Sub, Kasai, Shigeru, Okaya, Keiko, Iseki, Yasushi
• Format: Article
• Language: English
• Subjects: image guidance; machine learning; markerless tracking; real‐time image processing; rotating gantry; scanned carbon‐ion beam
• ISSN: 0094-2405; 2473-4209
• DOI: 10.1002/mp.13403

Purpose To perform the final quality assurance of our fluoroscopic‐based markerless tumor tracking for gated carbon‐ion pencil beam scanning (C‐PBS) radiotherapy using a rotating gantry system, we evaluated the geometrical accuracy and tumor tracking accuracy using a moving chest phantom with simulated respiration. Methods The positions of the dynamic flat panel detector (DFPD) and x‐ray tube are subject to changes due to gantry sag. To compensate for this, we generated a geometrical calibration table (gantry flex map) in 15° gantry angle steps by the bundle adjustment method. We evaluated five metrics: (a) Geometrical calibration was evaluated by calculating chest phantom positional error using 2D/3D registration software for each 5° step of the gantry angle. (b) Moving phantom displacement accuracy was measured (±10 mm in 1‐mm steps) with a laser sensor. (c) Tracking accuracy was evaluated with machine learning (ML) and multi‐template matching (MTM) algorithms, which used fluoroscopic images and digitally reconstructed radiographic (DRR) images as training data. The chest phantom was continuously moved ±10 mm in a sinusoidal path with a moving cycle of 4 s and respiration was simulated with ±5 mm expansion/contraction with a cycle of 2 s. This was performed with the gantry angle set at 0°, 45°, 120°, and 240°. (d) Four types of interlock function were evaluated: tumor velocity, DFPD image brightness variation, tracking anomaly detection, and tracking positional inconsistency in between the two corresponding rays. (e) Gate on/off latency, gating control system latency, and beam irradiation latency were measured using a laser sensor and an oscilloscope. Results By applying the gantry flex map, phantom positional accuracy was improved from 1.03 mm/0.33° to